The composition and pharmacological action of biologically active substances in the plants of the genus Ferula


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Abstract

Ferula has been used in folk medicine in the Central Asia countries, Iran, China, and India since ancient times. The genus Ferula plants widely distributed in Southern and Central Tajikistan contain terpenoid compounds, coumarins, esters of organic acids, peptides, carbohydrates, etc. The biologically active compounds contained in the genus Ferula plants exhibit various pharmacological activities: antioxidant, antileishmanial, anticonvulsant, antidiabetic, antispasmodic, antihypertensive, antinociceptive, and others. Ferulas are a rich source of gum resin that is widely used in traditional medicine of the peoples of the world. Gum resin possesses sedative, carminative, antispasmodic, expectorant, laxative, analgesic, anthelmintic, antiseptic, and diuretic activities and has aphrodisiac signs, owing to which it is used in animal husbandry to increase the fertility of livestock. The plants of the genus Ferula are promising raw materials for the design of novel highly effective medicines showing different pharmacological types of action.

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About the authors

Olga Anatolyevna Popova

Research Center for Examination of Medical Products, Ministry of Health of the Russian Federation

Email: popovaoa@expmed.ru
Head of the Laboratory of Chemical and Pharmaceutical Preparations № 2

Gulomkodir Mukkamal Bobizoda

S. Aini Tajik State Pedagogical University

Email: bobievgm@rambler.ru
Professor of the Department of Organic Chemistry

Natalya Dmitrievna Bunyatyan

Research Center for Examination of Medical Products, Ministry of Health of the Russian Federation; I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: ndbun@mail.ru
Head of the Department of Pharmaceutical Technology and Pharmacology

Irina Petrovna Remezova

Pyatigorsk Medical and Pharmaceutical Institute, Branch, Volgograd State Medical University

Email: i.p.remezova@pmedpharm.ru
Professor of the Department of Toxicological and Analytical Chemistry

Irina Alexandrovna Samylina

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: laznata@mail.ru
Professor of the Department of the Pharmaceutical Natural Science

Aleksey Borisovich Prokofyev

Research Center for Examination of Medical Products, Ministry of Health of the Russian Federation; I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: prokofyev56@gmail.com
Director of the Center for Clinical Pharmacology of the SCEEMP; Professor of the Department of Pharmacology and Propaedeutics of Internal Diseases

Vladimir Aleksandrovich Evteev

Research Center for Examination of Medical Products, Ministry of Health of the Russian Federation

Email: pharmchemist@gmail.com
Senior Analyst of the Center for Clinical Pharmacology

Mikhail Mikhailovich Sapovsky

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: michael.sapovsky@mpbio.com
Professor of the Department of Pharmaceutical Technology and Pharmacology

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