Macroand microscopic analysis of the herbal sedative composition

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Abstract

Introduction. Solving the problems of psychoemotional health is one of the priorities of modern medicine. An increase in the level of stress and anxiety can be expressed not only in a worsening of psychological well-being, but also in the development of somatic diseases. Sedative medicines are one of the most effective and promising areas of pharmacotherapy.

Objective: to conduct a pharmacognostic analysis of the self-developed sedative medicinal herbs composition to establish the authenticity of the components included to ensure the possibility of introducing the medicine into pharmaceutical practice.

Material and methods. The object of the study is a four-component sedative herbal composition consisting of the herb of motherwort cordial (common motherwort) (Leonuruscardiaca L.), herb of St. John's wort (Hypericumperforatum L.), herb of lemon balm (Melissa officinalis L.) and herb of thyme (Thymus serpyllum L.). Methods - techniques of macro- and microscopic analysis.

Results. The characteristics of the authenticity of the herbal sedative composition, including a description of external signs and microscopic analysis, are determined.

Conclusion. The analysis was carried out which is necessary stage for the possibility of introduction of the medicine into pharmaceutical practice.

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About the authors

Yulia Eduardovna Prozhogina

All-Russian Scientific Research Institute of Medicinal and Aromatic

Author for correspondence.
Email: yulia-pro93@mail.ru
Applicant for a Degree Candidate of Pharmaceutical Sciences

Marina Arkadyevna Javakhyan

All-Russian Scientific Research Institute of Medicinal and Aromatic; Lomonosov Moscow State University

Email: akopovamarina13@mail.ru
Chief Researcher; Associate Professor of the Department of Pharmaceutical Technology

Natalia Vladimirovna Bobkova

Sechenov First Moscow State Medical University (Sechenov University)

Email: bobkovamma@mail.ru
Professor of Pharmaceutical Natural Sciences Department, Institute of Pharmacy

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2. Fig. 1. Macroscopic analysis of sedative composition. External signs of crushed grass: 1 – external signs of crushed St. John's wort grass (optical magnification ×10); 2 – external signs of crushed motherwort grass (optical magnification ×15); 3 – external signs of crushed melissa grass (optical magnification ×10); 4 – external signs of crushed thyme grass (optical magnification ×10)

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3. Fig. 2. Sedative composition. Macroscopic analysis. External signs of composition (optical magnification ×10): 1, 6 – St. John's wort leaf; 2 – motherwort leaf; 3 – melissa flower; 4 – St. John's wort flower petal; 5 – thyme leaf

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4. Fig. 3. Sedative composition. Motherwort grass: 1 – fragment of the epidermis of the leaf: stomatal complex of the anomocyte type (optical magnification ×400); 2 – fragment of the leaf edge: an essential oil gland, a simple multicellular hair (optical magnification ×400); 3 – a fragment of a leaf, an essential oil gland (a), a glandular hair (b) (optical magnification ×400); 4 – a fragment of a calyx, an essential oil gland (a), a simple multicellular hair (b) (optical magnification ×100)

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5. Fig. 4. Sedative composition. St. John 's Wort herb: 1 – fragment of a flower with stamens (optical magnification ×40); 2 – a fragment of a leaf, rounded colorless receptacles (a) and receptacles with oily pigmented contents (b) (optical magnification ×40); 3 – a fragment of a leaf, oblong receptacles along the veins with oily contents (optical magnification ×400); 4 – a fragment of a petal, large containers with pigmented contents (optical magnification ×40)

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6. Fig. 5. Sedative composition. Melissa grass, leaf blade: 1 – head hair (optical magnification ×400); 2 –a simple multicellular hair (optical magnification ×400); 3 – an essential oil gland (optical magnification ×400); 4 – trichomes (optical magnification ×40)

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7. Fig. 6. Sedative composition. Thyme herb: 1 – flower corolla, essential oil gland (optical magnification ×400); 2 – leaf fragment: an essential oil gland (а), a clear-shaped thickening of the cell walls (b); stomatal complex of the diacyte type (c) (optical magnification ×400); 3 – fragment of a flower cup, simple multicellular hairs (optical magnification ×400)

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