Vol 71, No 5 (2022)

Introduction. Tuberosus chin (Lathyrus tuberosus L.) is a plant widely represented in the chernozem zone of Russia. It contains various groups of biologically active substances: flavonoids, polysaccharides, terpenoids, tannins, amino acids. The plant is used in folk medicine. There are no data on the morphological and microscopic examination of the raw materials of the Lathyrus tuberosus.

Objective: establishing indicators of the authenticity of the of Lathyrus tuberosus herb, including studies of morphological and microdiagnostic characteristics of raw materials.

Material and methods. As an object of study was used the aerial part of the Lathyrus tuberosus, both fresh and dried, collected in the Kursk region in 2019-2021. Macroscopic studies were carried out with the naked eye and using a binocular loupe. Microscopic signs of various organs of the Lathyrus tuberosus were analyzed by preparing temporary preparations, using a «Micromed C1 LED» microscope with a digital attachment.

Results. Morphological and microdiagnostic features of Lathyrus tuberosus herb, including stem, leaf, calyx and corolla, have been established. The main microdiagnostic features are: the pedicle is of a bundle type of structure, the vascular bundles are closed, collateral. Anomocytic stomata. The pubescence includes three types of hairs: three-celled with thick-walled cells, their basal part consists of two small prosenchymal cells, the terminal cell is long with a pointed apex (leaflets of a compound leaf); simple thin-walled one-two-celled hairs with a pointed apex and simple thin-walled two-three-celled hairs with an elongated terminal cell and a rounded apex with granular contents (calyx). The edge of the corolla has thin-walled papillary outgrowths. Prismatic crystals are located along the veins of the leaflets of the compound leaf and the calyx.

Conclusion. The investigation has provided new data on the morphological and anatomical structure of Lathyrus tuberosus herb.

Introduction. Solving the problems of psychoemotional health is one of the priorities of modern medicine. An increase in the level of stress and anxiety can be expressed not only in a worsening of psychological well-being, but also in the development of somatic diseases. Sedative medicines are one of the most effective and promising areas of pharmacotherapy.

Objective: to conduct a pharmacognostic analysis of the self-developed sedative medicinal herbs composition to establish the authenticity of the components included to ensure the possibility of introducing the medicine into pharmaceutical practice.

Material and methods. The object of the study is a four-component sedative herbal composition consisting of the herb of motherwort cordial (common motherwort) (Leonuruscardiaca L.), herb of St. John's wort (Hypericumperforatum L.), herb of lemon balm (Melissa officinalis L.) and herb of thyme (Thymus serpyllum L.). Methods - techniques of macro- and microscopic analysis.

Results. The characteristics of the authenticity of the herbal sedative composition, including a description of external signs and microscopic analysis, are determined.

Conclusion. The analysis was carried out which is necessary stage for the possibility of introduction of the medicine into pharmaceutical practice.

Introduction. Pharmaceutical development of medicines in the form of therapeutic systems with long-lasting effects is a priority area of pharmaceutical technology. Currently, the share of medicines registered in the State Register of Medicines as therapeutic systems is insignificant. In addition, some signs and characteristics of registered therapeutic systems (in particular, transdermal) have almost identical signs of the following dosage forms: transdermal patches, medical patches, films. In this connection, the analysis and systematization of regulatory documentation of dosage forms having similar signs and characteristics is timely and relevant.

Objective: to determine the differential signs of therapeutic systems, as a dosage form, based on the analysis of regulatory documentation and scientific and technical literature.

Material and methods. Regulatory documentation was used as research materials: general pharmacopoeia articles of the State Pharmacopoeia of the XIV ed. on medicinal forms "Therapeutic systems", "Transdermal Plasters", "Medical Plasters", "Films"; State Register of Medicines; electronic resources eLibrary, CyberLeninka. Research methods - content analysis and system analysis of regulatory documentation, the State Register of Medicines, scientific and technical publications.

Results. The analysis of the domestic market of registered medicines in the form of therapeutic systems is carried out; the main characteristics of the dosage form "Therapeutic systems" are determined, allowing to differentiate it from similar dosage forms; the classification of the dosage form "Therapeutic Systems" is proposed, which allows to fully characterize the dosage form.

Conclusion. There are eight trade names of medicines on the pharmaceutical market of the Russian Federation, the form of release of which are therapeutic systems: transdermal, intrauterine, vaginal. The main characteristics of the dosage form "Therapeutic systems" have been determined, which allow differentiating it from similar dosage forms that provide a long-lasting systemic or local pharmacological effect. The classification of the dosage form "Therapeutic systems" is proposed, which allows it to fully characterize.

Introduction. The modern multi-level system of higher education, as well as the necessary requirements for advanced training and retraining, do not always take into account the peculiarities of training, building a trajectory for professional development and promotion of pharmacist officers, taking into account the specifics of the tasks they solve in the course of service and combat activities.

Objective. To analyze the prospects for professional development and assess the possibilities for promotion of pharmacist officers, taking into account trends in domestic pharmaceutical education and the current staffing needs of the medical service of the RF Armed Forces.

Material and methods. The research materials were legislative and regulatory legal acts of the Russian Federation, regulatory legal acts of federal executive authorities, including the Ministry of Defense of the Russian Federation, in the field of healthcare and education. In the course of the research, content analysis, historical, structural-logical and system analysis were used.

Results. The main areas of training of military pharmaceutical personnel are presented, depending on the levels of higher education, as well as the features of advanced training and retraining. The article describes the requirements for the level of education of pharmacist officers in accordance with their official designation in relation to accepted professional standards, as well as the procedure for their admission to practical activities within the framework of the mandatory accreditation procedure and inclusion in the system of continuous medical (pharmaceutical) education (continuous professional development). The main problematic issues related to the implementation of professional standards in the performance of the functional duties of pharmacist officers in the military and hospital levels of the medical service of the Armed Forces have been identified and analyzed. The discrepancy between the nomenclature of officer pharmaceutical positions and the nomenclature of positions adopted in civil health care is shown.

Conclusion. The need for an integrated approach to the training of pharmaceutical specialists for civil and military healthcare, harmonization of accreditation procedures for compliance with the functional and service-combat duties performed, as well as ensuring career growth and compliance with positions held on the basis of uniform qualification requirements and participation in the system of continuous professional development was emphasized.

Introduction: to date, for the experimental evaluation of the antiviral activity of drugs, a number of in vitro and in vivo methods based on the use of virus strains is used. However, the disadvantage of all these methods is that it does not always happen that one or another virus strain is available to the experimenter, which makes it difficult to assess the antiviral activity of the drug. Purpose of the study: development of a method for evaluating the antiviral evaluation of drugs, without the use of virus strains.

Material and methods: the authors suggest that antiviral preparations will have a protective effect on erythrocytes under conditions of osmotic hemolysis, as well as have a protective effect on the cell under conditions of a viral attack of the cell. It should be noted that the literature does not provide information on the protective properties of antiviral agents under conditions of osmotic hemolysis, which makes this development unique. In the development, a method was used based on the assessment of the osmotic activity of erythrocytes for a new purpose.

Results: according to the results of the experiment, it was found that reference antiviral preparations have a protective effect on blood cells under conditions of osmotic hemolysis.

Conclusion: a new method has been developed based on the ability of an antiviral drug to have a protective effect on erythrocytes under conditions of osmotic hemolysis, which can be recommended for experimental study of the antiviral activity of medicinal and pharmacological preparations with antiviral activity.