Study of the hepatoprotective activity of pharmaceutical substance of plant origin in the form of a dry extract based on milk thistle, columns with stigmas of corn and peppermint
- Authors: Imamaliev B.A.1, Salimova N.C.2, Sultanova R.K.2, Isadjanov M.S.1
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Affiliations:
- «Med Standart» Research Center
- Tashkent Pharmaceutical Institute
- Issue: Vol 72, No 2 (2023)
- Pages: 49-54
- Section: Pharmacology: Experiment and clinic
- URL: https://journals.eco-vector.com/0367-3014/article/view/321931
- DOI: https://doi.org/10.29296/25419218-2023-02-08
- ID: 321931
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Abstract
Introduction. Liver diseases continue to be one of the most common in the clinic of internal diseases. The problem of alcoholic fatty liver disease, and especially due to the current pandemic of type 2 diabetes mellitus and obesity – non-alcoholic fatty liver disease, has become one of the leading world problems of modern medicine in recent years. In the treatment of these diseases, as well as in almost all other liver diseases, one of the leading places belongs to hepatoprotectors.
Objective: was to study the hepatoprotective activity of pharmaceutical substance of plant origin (PSPO) in the form of a dry extract based on the fruits of milk thistle, columns with stigmas of corn and peppermint leaves.
Material and methods. The study of the hepatoprotective activity of preparation was carried out on a model of toxic (tetrachloromethane) hepatitis.
Results. The data obtained indicate the presence in the test preparation of significant hepatoprotective activity comparable to the reference preparation.
Conclusion. The studied PSPO in the form of a dry extract based on milk thistle fruits, columns with stigmas of corn, peppermint leaves has a significant hepatoprotective activity that is not inferior to the reference preparation.
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About the authors
Bakhtiyor A. Imamaliev
«Med Standart» Research Center
Author for correspondence.
Email: teokrat_1985@mail.ru
ORCID iD: 0000-0002-7526-5105
PhD in Pharmaceutical Sciences, Senior Sientific Researcher, Head of Scientific Center
Uzbekistan, Karasarai St., 343, Tashkent, 100049Nafisa Ch. Salimova
Tashkent Pharmaceutical Institute
Email: nafisaxon1993@inbox.ru
ORCID iD: 0000-0001-6325-1542
Assistant of the Chair of Pharmacology and Clinical Pharmacy
Uzbekistan, Aibek St., 45, Tashkent, 100015Rano Kh. Sultanova
Tashkent Pharmaceutical Institute
Email: r.kh.sultanova@gmail.com
ORCID iD: 0000-0002-3983-3419
PhD in Pharmaceutical Sciences, Associate Professor, Head of the Chair of Pharmacology and Clinical Pharmacy
Uzbekistan, Aibek St., 45, TashkentMuzaffar S. Isadjanov
«Med Standart» Research Center
Email: muzaffarm_13@mail.ru
ORCID iD: 0000-0001-8458-3220
laboratory doctor
Russian Federation, Karasarai St., 343, Tashkent, 100049References
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