Modern aspects of the development of bioadhesive dosage forms for the oral cavity (review)

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Abstract

The creation of dosage forms with the ability to bioadhesive is an urgent direction in the development of pharmaceutical technology. This review systematizes modern developments of bioadhesive drugs for use in the oral cavity, including films, gels, tablets and micro-/nanoparticles. Special attention is paid to bioadhesive polymers, their systematization and description of properties and methods of inclusion in the composition of dosage forms. The key aspects of the structure of the oral mucosa that determine the effectiveness of bioadhesion and methods for measuring mucoadhesive properties (in vitro and in vivo), including stretching tests, rheological methods, the use of flow systems, etc. are considered. Examples of commercial drugs available on the Russian market and variants of formulations of dosage forms described in scientific publications are given. The review also addresses the issue of standardization of testing methods for these dosage forms, including the use of synthetic and natural mucosal analogues. In general, the development of bioadhesive medicines for the oral cavity opens up new opportunities for the treatment of local and systemic diseases, combining ease of use, prolonged effect and reduction of systemic adverse reactions.

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About the authors

Maria N. Anurova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: anurova_m_n@staff.sechenov.ru
ORCID iD: 0000-0002-7649-9616

PhD (Pharm.), Associate Professor of the Department of Pharmaceutical Technology at the A.P. Nelyubin Institute of Pharmacy

Russian Federation, Trubetskaya St., 8, Moscow, 119991

Kirill E. Petrulenko

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: kerjakowski@yandex.ru
ORCID iD: 0009-0000-6828-4976

is a postgraduate student at the Department of Pharmaceutical Technology at the A.P. Nelyubin Institute of Pharmacy

Russian Federation, Trubetskaya St., 8, Moscow, 119991

Alexey R. Kuzmin

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: repzcraft@gmail.com
ORCID iD: 0009-0004-0711-6310

is a postgraduate student at the Department of Pharmaceutical Technology at the A.P. Nelyubin Institute of Pharmacy

Russian Federation, Trubetskaya St., 8, Moscow, 119991

Ivan I. Krasnyuk

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: krasnyuki@mail.ru
ORCID iD: 0000-0002-7242-2988

Doctor of Pharmaceutical Sciences, Professor, Head of the Department of Pharmaceutical Technology at the A.P. Nelyubin Institute of Pharmacy

Russian Federation, Trubetskaya St., 8, Moscow, 119991

Natalia Borisovna Demina

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: demina_n_b@staff.sechenov.ru
ORCID iD: 0000-0003-4307-8791

Doctor of Pharmaceutical Sciences, Professor of the Department of Pharmaceutical Technology at the A.P. Nelyubin Institute of Pharmacy

Russian Federation, Trubetskaya St., 8, Moscow, 119991

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2. Fig. 1. Mechanism of mucoadhesion

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3. Fig. 2. Equipment for determining the tensile and tear strength. Note. а – modified lever scale: 1 – is a lever, 2 – is a device for holding DF or AS samples and mucosal samples; 3 – is the surface to which the DF or AS is attached; 4 – is the DF or AS sample; 5 – is the mucous membrane or its equivalent; 6 – is the load; б – Texture Analyzer (LLOYD Instruments, TA plus Ametek, United Kingdom); в – Electronic Tensile Tester GBL-H (GBPI, China); г – dynamic contact angle meter (CY Scientific Instrument, China)

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4. Fig. 3. Flow system with HPLC analysis or fluorescence labeling of mucoadhesive

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