Design and standardization of the composition of suppositories containing antiviral components


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Introduction. The antiviral drug Acyclovir is widely used in medical practice. The new antiviral drug Ryamilovir has recently appeared on the Russian pharmaceutical market. Objective: to design suppositories containing 2 antiviral drugs: Acyclovir and Ryamilovir. Methods. The investigation used the following methods: thin layer chromatography (TLC), spectrophotometry, semipermeable membrane dialysis, and statistical processing of the results. Results. The composition of bases and excipients was selected: it is recommended to use cocoa butter and aerosil as a suppository base under pharmacy conditions and polyethylene oxide and glyciram under production-line conditions. Components were identified using TLC and quantified by spectrophotometry, which allows one to determine both components in one sample. Conclusion. The composition of the suppositories containing 2 antiviral drugs Acyclovir and Ryamilovir was designed. A procedure was proposed to identify components using TLC and quantitative spectrophotometric determination.

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作者简介

Anna Saenko

Pyatigorsk Medical Pharmaceutical Institute, Branch, Volgograd State Medical University

Email: anitakool@mail.ru
teacher of the Department of pharmacy FPO Pyatigorsk medical and pharmaceutical Institute-a branch of the VSTU MOH, candidate of pharmaceutical Sciences

Eleonora Stepanova

Pyatigorsk Medical Pharmaceutical Institute, Branch, Volgograd State Medical University

Email: E.F.Stepanova@mail.ru
Professor of pharmaceutical technology and medical biotechnology Department

John Lazaryan

Pyatigorsk Medical Pharmaceutical Institute, Branch, Volgograd State Medical University

Email: s.lazaryan@pmedpharm.ru
head of the Department of pharmaceutical and Toxicological chemistry

Alexander Petrov

Ural state medical University

Email: uniitmp@yandex.ru
Professor of the Department of pharmacy

Irina Kul

Pyatigorsk Medical Pharmaceutical Institute, Branch, Volgograd State Medical University

Email: irinakool@mail.ru
senior lecturer of the Department of pharmaceutical and Toxicological chemistry

参考

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  3. Государственный реестр лекарственных средств [Электронный ресурс]. Режим доступа: https://grls. rosminzdrav.ru/Default.aspx
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  6. Саенко А.Ю., Степанова Э.Ф., Петров А.Ю., Куль И.Я. Валидационная оценка методик анализа суппозиториев с диклофенаком натрия и кислотой ацетилсалициловой. Фундаментальные исследования, 2013; 10 (12): 2710-4.
  7. Государственная фармакопея Российской Федерации, XIII изд. Т. 1. М.: МЗ РФ, 2015; 1294.

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