SORPTION AND DESORPTION OF LIQUID PLANT EXTRACT

Introduction. Alcoholic plant extracts are widely used in the therapy of many diseases. However, this formulation has a number of disadvantages that can be eliminated by transferring the liquid extract to the solid state. In this case, the adsorption technique allows one to preserve the entire complex of biologically active substances of the extract and does not affect its therapeutic efficacy. Objective: to select the optimal adsorbent for converting a liquid plant extract to the solid state, by using the drug Rotocan as an example. Materials and methods. The investigation object was the combined plant remedy Rotokan that is a mixture of liquid extracts from wild chamomile (Matricaria chamomilla) flowers, marigold (Calendula) flowers, and milfoil (Achillea) herb (hereinafter referred to as the extract). The investigators used solid carriers having sorption activity, such as microcrystalline cellulose (MCC), colloidal silicon dioxide (CSD), and microcapsules (MC) of vaterite, which were prepared extempore. Adsorption was carried out at room temperature in a glider mixer at different ratios of the extract and solid carriers. The technological characteristics of the adsorbents before and after adsorption were established according to the requirements of the Russian Federation State Pharmacopoeia, 13th edition (RF SP, 13th Edition) by using an electronic GTB flow tester and a SWM 102 bulk density tester. A Cary-100 UV spectrophotometer was used to spectrophotometrically determine flavonoids calculated with reference to luteolin. Results. It was established that the technological characteristics of the microcapsules of vaterite before and after the adsorption of the extract did not meet the requirements of the RF SP, 13th Edition. When desorbed from MCC and CSD powders, the biologically active substances of the extract were transferred to a desorbate, unlike MC, the desorbate from which failed to react to flavonoids and to quantify the latter. Conclusion. To convert the amount of plant extracts from wild chamomile flowers, marigold flowers, and milfoil herb from a liquid formulation to the solid phase by adsorption, it is promising to use microcellulose and colloidal silicon dioxide.

combined plant extract, sorption, desorption, microcrystalline cellulose, colloidal silicon dioxide, vaterite, microcapsules