Study of the specific activity of an innovative dosage form of a chemotherapeutic agent
- 作者: Naryshkin S.R.1, Krasnyuk I.I.1, Krasnyuk I.I.1, Fateeva T.V.2, Mizina P.G.2, Belyatskaya A.V.1, Stepanova O.I.1, Smolyarchuk E.A.1, Plakhotnaia O.N.1, Bokov D.O.1, Grikh V.V.1, Boldina M.S.1, Rastopchina O.V.1, Bobrov I.S.1
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隶属关系:
- Sechenov First Moscow State Medical University (Sechenov University)
- All-Russian research Institute of Medicinal and Aromatic plants
- 期: 卷 71, 编号 4 (2022)
- 页面: 19-25
- 栏目: Pharmaceutical chemistry and pharmacognosy
- URL: https://journals.eco-vector.com/0367-3014/article/view/113735
- DOI: https://doi.org/10.29296/25419218-2022-04-03
- ID: 113735
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Introduction. On the basis of Sechenov University departments, an innovative antimicrobial and antiprotozoal drug – metronidazole in the form of effervescent tablets has been developed. Together with the «All-Russian research Institute of Medicinal and Aromatic plants», the antimicrobial activity of the developed instant tablets was studied. Metronidazole has been successfully used for more than 60 years to treat diseases of the gastrointestinal tract, genitourinary system; it is actively used in dental and dermatological practice. At the same time, there are currently no instant dosage forms of metronidazole on the pharmaceutical market of the Russian Federation that allow patients to use the drug for both internal and topical use.
Objective: to determine the antimicrobial activity of an experimentally developed new dosage form of metronidazole – effervescent tablets in comparison with ready-made dosage forms of metronidazole: infusion solution and tablets.
Material and methods. Metronidazole (substance), developed effervescent metronidazole tablets (composition No. 2 and No. 3), their placebo, sodium benzoate (auxiliary substance – sliding), industrially manufactured tablets and infusion solution. Determination of bacteriostatic and fungistatic activity was studied by dilution method. Pathogenic gram-positive and gram-negative bacteria, yeast-like and mycelial fungi were used. When determining the bacteriostatic activity of the studied samples, meat-peptone broth was used. When determining the fungistatic activity – a liquid Saburo medium.
Results. The data obtained indicate that all samples containing metronidazole in their composition practically coincide in antimicrobial (bacteriostatic and fungistatic) activity with each other and with the activity of the metronidazole substance included in their composition, which indirectly confirms the complete release of the substance from experimental dosage forms and the absence of formation of insoluble complexes with placebo that could inhibit the release of metronidazole.
Conclusion. The conducted studies have established the presence of antimicrobial activity in the developed effervescent metronidazole tablets.
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作者简介
Savva Naryshkin
Sechenov First Moscow State Medical University (Sechenov University)
Email: savva.naryshkin@gmail.com
ORCID iD: 0000-0003-1775-4805
postgraduate student, department of analytical, physical and colloid chemistry, Institute of Pharmacy named after A.P. Nelyubin
俄罗斯联邦, st. Trubetskaya, 8–2, Mosсow, 119991Ivan Krasnyuk
Sechenov First Moscow State Medical University (Sechenov University)
Email: krasnyuk.79@mail.ru
ORCID iD: 0000-0001-8557-8829
professor, doctor of pharmaceutical science, PhD, head of department of analytical, physical and colloid chemistry, Institute of Pharmacy named after A.P. Nelyubin
俄罗斯联邦, st. Trubetskaya, 8–2, Mosсow, 119991Ivan Krasnyuk
Sechenov First Moscow State Medical University (Sechenov University)
Email: krasnyuki@mail.ru
ORCID iD: 0000-0002-7242-2988
professor, doctor of pharmaceutical science, head of department of pharmaceutical technology, Institute of Pharmacy named after A.P. Nelyubin
俄罗斯联邦, st. Trubetskaya, 8–2, Mosсow, 119991Tatiana Fateeva
All-Russian research Institute of Medicinal and Aromatic plants
Email: fateeva2151@mail.ru
ORCID iD: 0000-0002-8231-0621
head of the microbiological research laboratory, leading researcher
俄罗斯联邦, st. Grina, 7/1, Moscow, 117216Prascovia Mizina
All-Russian research Institute of Medicinal and Aromatic plants
Email: pg-mizina@vilarnii.ru
deputy director for scientific work, professor, doctor of pharmaceutical science
俄罗斯联邦, st. Grina, 7/1, Moscow, 117216Anastasiya Belyatskaya
Sechenov First Moscow State Medical University (Sechenov University)
Email: av.beliatskaya@mail.ru
ORCID iD: 0000-0002-8214-4483
Candidate of pharmaceutical sciences, docent of department of pharmaceutical technology, Institute of Pharmacy named after A.P. Nelyubin
俄罗斯联邦, st. Trubetskaya, 8–2, Mosсow, 119991Ol'ga Stepanova
Sechenov First Moscow State Medical University (Sechenov University)
Email: o.i.nikulina@mail.ru
ORCID iD: 0000-0002-9885-3727
candidate of pharmaceutical science, docent of department of pharmacology, Institute of Pharmacy named after A.P. Nelyubin
俄罗斯联邦, st. Trubetskaya, 8–2, Mosсow, 119991Elena Smolyarchuk
Sechenov First Moscow State Medical University (Sechenov University)
Email: smolyarchuk@mail.ru
ORCID iD: 0000-0002-2615-7167
candidate of medical science, docent, head of department of pharmacology, Institute of Pharmacy named after A.P. Nelyubin
俄罗斯联邦, st. Trubetskaya, 8–2, Mosсow, 119991Ol'ga Plakhotnaia
Sechenov First Moscow State Medical University (Sechenov University)
Email: plahotnaya.o@mail.ru
ORCID iD: 0000-0001-7266-2933
candidate of chemical science, docent of department of analytical, physical and colloid chemistry, Institute of Pharmacy named after A.P. Nelyubin
俄罗斯联邦, st. Trubetskaya, 8–2, Mosсow, 119991Dmitrij Bokov
Sechenov First Moscow State Medical University (Sechenov University)
Email: fmmsu@mail.ru
ORCID iD: 0000-0003-2968-2466
candidate of pharmaceutical science, docent of department of analytical, physical and colloid chemistry, Institute of Pharmacy named after A.P. Nelyubin
俄罗斯联邦, st. Trubetskaya, 8–2, Mosсow, 119991Viktoriya Grikh
Sechenov First Moscow State Medical University (Sechenov University)
Email: viktoriya.grikh@mail.ru
ORCID iD: 0000-0003-1614-1070
candidate of pharmaceutical science, docent of department of analytical, physical and colloid chemistry, Institute of Pharmacy named after A.P. Nelyubin
俄罗斯联邦, st. Trubetskaya, 8–2, Mosсow, 119991Maria Boldina
Sechenov First Moscow State Medical University (Sechenov University)
Email: mar-usy@yandex.ru
ORCID iD: 0000-0002-1620-699X
postgraduate student, department of analytical, physical and colloid chemistry, Institute of Pharmacy named after A.P. Nelyubin
俄罗斯联邦, st. Trubetskaya, 8–2, Mosсow, 119991Olga Rastopchina
Sechenov First Moscow State Medical University (Sechenov University)
Email: rastop0309@yandex.ru
ORCID iD: 0000-0002-5443-6980
Candidate of pharmaceutical sciences, docent of department of pharmaceutical technology, Institute of Pharmacy named after A.P. Nelyubin
俄罗斯联邦, st. Trubetskaya, 8–2, Mosсow, 119991Ivan Bobrov
Sechenov First Moscow State Medical University (Sechenov University)
编辑信件的主要联系方式.
Email: bobrov2602@yandex.ru
ORCID iD: 0000-0001-8263-5541
student of Institute of Pharmacy named after A.P. Nelyubin
俄罗斯联邦, st. Trubetskaya, 8–2, Mosсow, 119991参考
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