Development of technology for obtaining a dry extract from the Scutellaria Iscanderi Juz. herb

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Introduction. Plants of the genus Scutellaria L. are widely used in medicine in the treatment of various diseases. One of the common species of the genus Scutellaria L. in Uzbekistan is Scutellaria Iscanderi Juz., which contains flavonoids, tannins and has an effective sedative effect.

Objective: to develop an optimal technology for the production of dry extract from the S. Iscanderi herb.

Material and methods. The object of the study is the S. Iscanderi herb, as well as liquid and dry extracts based on it. Determination of technological parameters of the extraction process was carried out in accordance with well-known methods. The quantitative content of the sum of flavonoids was determined by the spectrophotometric method, the content of tannins was determined by the method of volumetric permanganometric titration.

Results. A technology has been developed for obtaining a dry extract from the S. Iscanderi herb. The optimal extractant and extraction conditions were experimentally established.

Conclusion. The data on the substantiation of the technology for obtaining a dry extract from the S. Iscanderi herb is presented.

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作者简介

Shakhnoza Muratova

Uzbek Research Chemical-Pharmaceutical Institute named after A. Sultanov

编辑信件的主要联系方式.
Email: mshx2244@mail.ru
ORCID iD: 0000-0002-5510-5462

researcher

乌兹别克斯坦, Do’rmon yo’li str, 40, Tashkent, 100125

Mokhinur Ismailova

Tashkent Pharmaceutical Institute

Email: pharmokhinur@gmail.com
ORCID iD: 0000-0002-6739-4660

Doctor of Pharmaceutical Sciences, professor

乌兹别克斯坦, Oybek str, 45, Tashkent, 100015

Pazaat Ismailova

Uzbek Research Chemical-Pharmaceutical Institute named after A. Sultanov

Email: ipazaat@mail.ru
ORCID iD: 0000-0001-9987-5111

PhD in chemistry sciences, head of the laboratory

乌兹别克斯坦, Do’rmon yo’li str, 40, Tashkent, 100125

Ravshanjon Khalilov

Institute of Chemistry of Plant Substances named after Academician S.Yu. Yunusov of the Academy of Sciences of the Republic of Uzbekistan

Email: r.m.khalilov@mail.ru
ORCID iD: 0000-0003-0414-1049

Doctor of Technical sciences, leading researcher

乌兹别克斯坦, Mirzo Ulugbek str, 77, Tashkent, 100170

参考

  1. Minaeva V.G. Baikal skullcap Scutellaria baicalensis Georgi. Medicinal plants of Siberia. Novosibirsk: Nauka. Sib. department. 1991; 212–4 (in Russian)].
  2. Goldberg E.D., Dygai A.M., Litvinenko V.I., Popova T.P., Suslov N.I. Shlemnik Baikal. Phytochemistry and pharmacological properties. Tomsk. 1994; 222 (in Russian)].
  3. Litvinenko V.I., Popova T.P., Volovik V.G., Goldberg E.D., Dygai A.M., Suslov N.I. Phytochemistry and pharmacological properties of preparations of the Baikal Skullcap. Kharkiv, 2007; 763 (in Russian)].
  4. Chirikova N.K., Olennikov D.N., Tankhaeva L.M. Pharmacognostic study of the aboveground part of the Baikal Skullcap (Scutellaria baicalensis. Georg.) Chemistry of plant raw materials. 2009; 1: 73–8 (in Russian)].
  5. Olennikov D.N., Chirikova N.K., Tankhaeva L.M. Phenolic compounds of the Baikal Skullcap (Scutellaria baicalensis Georgi). Chemistry of plant raw materials. 2009; 4: 89–98 (in Russian)].
  6. Chemesova I.I. Flavonoids of species of the genus Scutellaria L. Plant resources. 1993; 29 (2): 89–99 (in Russian)].
  7. Shang X., He X., He X., Li M., Zhang R., Fan P., Zhang Q., Jia Z. The genus Scutellaria an ethnopharmacological and phytochemical review. J. Ethnopharmacol. 2010; 128: 279–313.
  8. Bardakci H., Acar E.T., Kırmızıbekme H. Simultaneous quantification of six flavonoids in four Scutellaria taxa by HPLC-DAD method. Brazilian journal of Pharmacognozi Revista Brasileira de Farmacognosia. 2019; 29 (1): 17–23. https://doi.org/10.1016/j.bjp.2018.09.006
  9. Karimov A.M., Botirov E.H. Structural diversity and the degree of study of flavonoids of the genus Scutellaria L. Chemistry of plant raw materials. 2016; 1: 5–28 (in Russian)].
  10. Karimov A.M., Mamatkhanova M.A., Batirov E.H., Khalilov R.M., Mamatkhanov A.U., Sagdullaev Sh.Sh., Syrov V.N. Sasmakov S.A., Egamova F.R., Khushbaktova Z.A., Ergasheva S.A. Method of obtaining a means having an adoptagenic effect. Patent of the Republic of Uzbekistan No. IAP 06277, published in the official bulletin. 2020; 9 (in Russian)].
  11. Ergasheva Sh.A., Mamatkhanova M.A., Nabiev A., Karimov A.M., Khalilov R.M., Mamatkhanov A.U. Development of a technological scheme for obtaining and studying the antihypoxic activity of dry extracts from the aboveground part of Scutellaria adenostegia. Chemical and Pharmaceutical journal. 2021; 55 (6): 28–33. doi: 10.30906/0023-1134-2021-55-6-28-33 (in Russian)].
  12. Ismailov A.I., Karinmdzhanov A.K., Khudaibergenov T., Latvineuko V. I., Popova T. P. Phenolic compounds of Scutellaria iscanderi. Chem Nat Compd. 1995; 31: 414. https://doi.org/10.1007/BF01165218.
  13. Ismailova P.L. Ismailova M. G., Muratova Sh.Kh. “Determination of the quantitative content of the sum of flavonoids and tannins in the dry extract of Scutellaria Iscandaria L” Pharmaceutical Journal No.2. Tashkent, 2020; 49 (in Russian)].
  14. Ismailova P.L., Abzalova N.A., Ismailova M.G. Study of the chemical composition and determination of the sum of flavonoids in the elevated part of the tincture of Scutellaria Iscanderi L. International Journal of Pharmaceutical Research. 2020; 12 (2): 203–10.
  15. Ismailova P.L, Ismailova M.G, Muratova Sh.Kh. "Study Of Toxicity and Pharmacological Activity Of Dry Extract Of Iskanderii Skullcap", Infection, Immunity and Pharmacology. journal Tashkent. 2019; 4: 20–8 (in Russian)].
  16. Malikov V.M., Yuldashev M.P. Phenolic compounds of plants of the genus Scutellaria L.: distribution, structure and properties. Chemistry of natures. soedin. 2002; 4: 299-324; 2002; 5: 385–407 (in Russian)].
  17. State Pharmacopoeia of the Russian Federation, XIV edition, Moscow, 2018; 1815 (in Russian)].

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