Analysis of experience in the use of individually manufactured drugs in psychiatric practice

Introduction. The article provides an analysis of the problematic issues that medical organizations and pharmacies face when using drugs manufactured according to extemporaneous prescriptions in clinical practice in psychiatric medical organizations.

Objective. The purpose of this study is to analyze the experience of using extemporaneous formulations in psychiatric practice in order to determine the frequency of its prescription in the treatment of mental disorders.

Material and methods. The study used: content analysis, observation method, documentary, systemic, statistical and other methods for studying drug prescriptions for psychiatric patients. The basis of the research was the specialized departments and hospitals of the Sverdlovsk Regional Psychiatric Hospital, namely, prescription sheets and requirements-invoices for medications prepared according to extemporaneous prescriptions for adult patients from 18 to 60 years old with a psychiatric history

Results and discussion. During the study, a decrease in interest in extemporaneously manufactured dosage forms included in the pharmaceutical manual in the section for psychiatrists was noted. 11 prescriptions with analgesic and sedative effects were selected from the Pallas's cat. A study of the frequency of prescription of individually prepared dosage forms showed that the prescription of the studied prescriptions to patients is uneven. More often, extemporaneously manufactured drugs are prescribed in hospitals, with priority given to infusions of sedative preparations, Pavlov’s mixture, sodium bromide powder with valerian root powder and Dobronravy drops are less commonly prescribed. In the narcological department, painkillers are more often prescribed: painkiller lotion and chloroform oil. In the women's outpatient department No.43 and the men's outpatient department No.44, extemporaneous medications are prescribed extremely rarely and mainly valerian-based drugs.

Rarely in doctors' prescriptions were drugs with outdated formulations observed, such as Bekhterev's mixture, suppositories with chloral hydrate, and Professor Sirotin's pills. The decrease in interest in extemporaneously manufactured drugs can be explained by the lack of necessary substances in pharmacies; in addition, clinical recommendations contain only registered drugs; the prescription of extemporaneous dosage forms requires consideration by a medical commission, which complicates the work of doctors.

Conclusion. Drugs of extemporaneous manufacture can be used more widely as an addition to the main therapy in the prevention and treatment of psychiatric nosologies, subject to the adoption of regulatory documents and introduction into circulation as part of clinical recommendations, as well as updating the manual formulation.