Physical fatigue and the morfofunctional state of myocardium in experimental chronic stress

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Abstract


The relationship between skeletal muscle fatigue and morpho-functional alterations in the myocardium was analyzed for the first time in Wistar male rats exposed to chronic stress. Post traumatic stress disorder (PTSD) was associated with signs of increased oxidative stress, which apparently induced the changes in cardiomyocyte structural components and the acceleration of skeletal and muscular fatigue.


About the authors

M. V. Kondashevskaya

Research institute of human morphology

Author for correspondence.
Email: marivladiko@mail.ru

Russian Federation, Moscow

V. E. Tseylikman

South Ural State University

Email: marivladiko@mail.ru

Russian Federation, Chelyabinsk

M. V. Komelkova

South Ural State University

Email: marivladiko@mail.ru

Russian Federation, Chelyabinsk

M. S. Lapshin

South Ural State University

Email: marivladiko@mail.ru

Russian Federation, Chelyabinsk

A. P. Sarapultsev

Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences;Ural Federal University

Email: marivladiko@mail.ru

Russian Federation, Ekaterinburg;Ekaterinburg

S. S. Lazuko

Educational Establishment Vitebsk State Order of Peoples' Friendship Medical University

Email: marivladiko@mail.ru

Belarus, Vitebsk

O. P. Kuzhel

Educational Establishment Vitebsk State Order of Peoples' Friendship Medical University

Email: marivladiko@mail.ru

Belarus, Vitebsk

E. B. Manukhina

South Ural State University;Institute Of General Pathology And Pathophysiology;University of North Texas Health Science Center

Email: marivladiko@mail.ru

Russian Federation, Chelyabinsk;Moscow;Fort Worth

H. F. Downey

South Ural State University;University of North Texas Health Science Center

Email: marivladiko@mail.ru

Russian Federation, Chelyabinsk;Fort Worth

M. V. Chereshneva

Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences

Email: marivladiko@mail.ru

Russian Federation, Ekaterinburg

V. A. Chereshnev

Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences;Ural Federal University

Email: marivladiko@mail.ru

Russian Federation, Ekaterinburg;Ekaterinburg

academician of the RAS

References

  1. Edmondson D., von Kanel R. Post-Traumatic Stress Disorder and Cardiovascular Disease // Lancet Psych. 2017. V. 4. P. 320-329.
  2. Pitman R.K., Rasmusson A. M., Koenen K. C., et al. Biological Studies of Post-Traumatic Stress Disorder // Nat. Rev. Neurosci. 2012. V. 13. P. 769-787.
  3. Koenen K.C., Sumner J. A., Gilsanz P., et al. Post-Traumatic Stress Disorder and Cardiometabolic Disease: Improving Causal Inference to Inform Practice // Psychol. Med. 2017. V. 47. P. 209-225.
  4. Oddone A.E., Dennis P. A., Calhoun P. S., et al. Orthostatic Hypotension in Young Adults with and without Posttraumatic Stress Disorder // Psychol. Trauma. 2015. V. 7. P. 229-233.
  5. Ebner K., Singewald N. Individual Differences in Stress Susceptibility and Stress Inhibitory Mechanisms // Curr. Opin. Behav. Sci. 2017. V. 14. P. 54-64.
  6. Zoladz P.R., Park C. R., Fleshner M., et al. Psychosocial Predator-Based Animal Model of PTSD Produces Physiological and Behavioral Sequelae and a Traumatic Memory Four Months Following Stress Onset // Physiol. Behav. 2015. V. 147. P. 183-192.
  7. Sapolsky R.M., Romero L. M., Munck A. U. How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions // Endocr. Rev. 2000. V. 21. P. 55-89.
  8. Lazuko S.S., Kuzhel O. P., Belyaeva L. E., Manukh- ina E. B., Fred Downey H., Tseilikman O. B., Komel- kova M. V., Tseilikman V. E. Posttraumatic Stress Disorder Disturbs Coronary Tone and Its Regulatory Mechanisms // Cell. Mol. Neurobiol. 2018. V. 38. P. 209-217.
  9. Клиническая лабораторная аналитика. Т. II. Частные аналитические технологии в клинической лаборатории / Под ред. В.В. Меньшикова. М.: Лабинформ-РАМЛД, 1999. 352 с.
  10. Волчегорский И.А., Долгушин И. И., Колесников О. Л., Цейликман В. Э. Экспериментальное моделирование и лабораторная оценка адаптационных реакций организма. Челябинск: Изд-во Челяб. гос. пед. ун-та, 2000. 167 с.
  11. Дубинина Е.Е., Бурмистров С. О., Ходов Д. А., Поротов И. Г. Окислительная модификация белков сыворотки крови человека, метод ее определения // Вопр. мед. химии. 1995. Т. 41. № 1. С. 24-26.
  12. Chandramouli C., Varma U., Stevens E. M., et al. Myocardial Glycogen Dynamics: New Perspectives on Disease Mechanisms // Clin. Exp. Pharmacol. Physiol. 2015. V. 42. P. 415-425.

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