Email this article Cationic copolymerisation of cholesterol vinyl ether with N-allenylpyrrolidone; a route to pharmacologically promising oligomers
- Authors: Markova M.V.1, Tatarinova I.V.1, Tarasova O.A.1, Apatrsin K.A.2, Kireeva V.V.2, Trofimov B.A.1
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Affiliations:
- Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
- Irkutsk Scientific Center, Siberian Branch of the Russian Academy of Sciences
- Issue: Vol 485, No 6 (2019)
- Pages: 697-700
- Section: Chemistry
- URL: https://journals.eco-vector.com/0869-5652/article/view/14409
- DOI: https://doi.org/10.31857/S0869-56524856697-700
- ID: 14409
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Abstract
Cationic copolymerization of cholesterol vinyl ether with N-allenylpyrrolidone yielded co-oligomers with molecular mass of 1200-2100. The polymerization of N-allenylpyrrolidone involves both 1,2- and 2,3-positions of the allenyl substituent to give four types of units as a result of prototropic isomerization of the initially formed structures. In the developed method, the composition of co-oligomers can be controlled and, hence, their hydrophilic/hydrophobic balance, solubility, and membranotropic properties can also be controlled to change the potential biological activity of the products.
About the authors
M. V. Markova
Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: boris_trofimov@irioch.irk.ru
Russian Federation, 1, Favorsky street, Irkutsk, 664033
I. V. Tatarinova
Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: boris_trofimov@irioch.irk.ru
Russian Federation, 1, Favorsky street, Irkutsk, 664033
O. A. Tarasova
Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: boris_trofimov@irioch.irk.ru
Russian Federation, 1, Favorsky street, Irkutsk, 664033
K. A. Apatrsin
Irkutsk Scientific Center, Siberian Branch of the Russian Academy of Sciences
Email: boris_trofimov@irioch.irk.ru
Russian Federation, 134, Lermontova street, Irkutsk, 664033
V. V. Kireeva
Irkutsk Scientific Center, Siberian Branch of the Russian Academy of Sciences
Email: boris_trofimov@irioch.irk.ru
Russian Federation, 134, Lermontova street, Irkutsk, 664033
B. A. Trofimov
Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
Author for correspondence.
Email: boris_trofimov@irioch.irk.ru
Academician of the Russian Academy of Sciences
Russian Federation, 1, Favorsky street, Irkutsk, 664033References
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