Cationic copolymerisation of cholesterol vinyl ether with N-allenylpyrrolidone; a route to pharmacologically promising oligomers

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Abstract


Cationic copolymerization of cholesterol vinyl ether with N-allenylpyrrolidone yielded co-oligomers with molecular mass of 1200-2100. The polymerization of N-allenylpyrrolidone involves both 1,2- and 2,3-positions of the allenyl substituent to give four types of units as a result of prototropic isomerization of the initially formed structures. In the developed method, the composition of co-oligomers can be controlled and, hence, their hydrophilic/hydrophobic balance, solubility, and membranotropic properties can also be controlled to change the potential biological activity of the products.


About the authors

M. V. Markova

Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences

Email: boris_trofimov@irioch.irk.ru

Russian Federation, 1, Favorsky street, Irkutsk, 664033

I. V. Tatarinova

Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences

Email: boris_trofimov@irioch.irk.ru

Russian Federation, 1, Favorsky street, Irkutsk, 664033

O. A. Tarasova

Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences

Email: boris_trofimov@irioch.irk.ru

Russian Federation, 1, Favorsky street, Irkutsk, 664033

K. A. Apatrsin

Irkutsk Scientific Center, Siberian Branch of the Russian Academy of Sciences

Email: boris_trofimov@irioch.irk.ru

Russian Federation, 134, Lermontova street, Irkutsk, 664033

V. V. Kireeva

Irkutsk Scientific Center, Siberian Branch of the Russian Academy of Sciences

Email: boris_trofimov@irioch.irk.ru

Russian Federation, 134, Lermontova street, Irkutsk, 664033

B. A. Trofimov

Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences

Author for correspondence.
Email: boris_trofimov@irioch.irk.ru

Russian Federation, 1, Favorsky street, Irkutsk, 664033

Academician of the Russian Academy of Sciences

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