Email this article Inhibition of neutrophil elastase and cathepsin G as a new approach to the treatment of psoriasis: from fundamental biology to development of new target-specific drugs
- Authors: Krasavin M.Y.1, Gureev M.A.2,3, Garabadzhiu А.V.2, Pashkin A.Y.4, Zhukov А.S.4, Khairutdinov V.R.4, Samtsov A.V.4, Shvets V.I.2,5,6
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Affiliations:
- Saint-Petersburg State University
- St.Petersburg State Technological Institute
- The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation
- S.M. Kirov Military Medical Academy
- "MIREA-Russian Technological University"
- Institute of General Pathology and Pathophysiology
- Issue: Vol 487, No 4 (2019)
- Pages: 455-459
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/15842
- DOI: https://doi.org/10.31857/S0869-56524874455-459
- ID: 15842
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Abstract
Psoriasis therapy remains extremely relevant area of modern drug design, due to necessity of adverse reactions reduction, inherent for actual methods of therapy. It has been established that two of serine proteases are key agents in psoriasis development: neutrophil elastase 1 (HNE1) and cathepsin G (CatG). Collected molecular data for presented targets forms the basis of molecular modeling strategy for search and identification of new target-specific inhibitors. The result of work is a group of high-priority small-molecule compounds with double-targeted affinity with ability to suppress pro-psoriatic processes, induced by observed serine proteases in the initial stage of disease.
About the authors
M. Y. Krasavin
Saint-Petersburg State University
Email: gar-54@mail.ru
Russian Federation, 7/9, Universitetskaya embankment, Saint-Petersburg, 199034
M. A. Gureev
St.Petersburg State Technological Institute; The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation
Email: gar-54@mail.ru
Russian Federation, 26, Moskovskii, S. Peterburg, 198013; 8-2, Trubetskaya street, Moscow, 119992
А. V. Garabadzhiu
St.Petersburg State Technological Institute
Author for correspondence.
Email: gar-54@mail.ru
Russian Federation, 26, Moskovskii, S. Peterburg, 198013
A. Y. Pashkin
S.M. Kirov Military Medical Academy
Email: gar-54@mail.ru
Russian Federation, 6G, Akad. Lebedeva street, Saint-Petersburg, 194044
А. S. Zhukov
S.M. Kirov Military Medical Academy
Email: gar-54@mail.ru
Russian Federation, 6G, Akad. Lebedeva street, Saint-Petersburg, 194044
V. R. Khairutdinov
S.M. Kirov Military Medical Academy
Email: gar-54@mail.ru
Russian Federation, 6G, Akad. Lebedeva street, Saint-Petersburg, 194044
A. V. Samtsov
S.M. Kirov Military Medical Academy
Email: gar-54@mail.ru
Russian Federation, 6G, Akad. Lebedeva street, Saint-Petersburg, 194044
V. I. Shvets
St.Petersburg State Technological Institute; "MIREA-Russian Technological University"; Institute of General Pathology and Pathophysiology
Email: gar-54@mail.ru
Academician of the Russian Academy of Sciences
Russian Federation, 26, Moskovskii, S. Peterburg, 198013; 78, Vernadskogo prospect, Moscow, 119454; 8, Baltiyskaya street, Moscow, 125315References
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