Email this article Bioinorganic markers of lens capsule barrier properties loss in age-related cataracts development
- Authors: Pakhomova N.A.1, Borisenko T.E.1, Novikov I.A.1, Avetisov S.E.1,2
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Affiliations:
- Research Institute of Eye Diseases
- The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation
- Issue: Vol 487, No 5 (2019)
- Pages: 592-595
- Section: Physiology
- URL: https://journals.eco-vector.com/0869-5652/article/view/15915
- DOI: https://doi.org/10.31857/S0869-56524875592-595
- ID: 15915
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Abstract
The study demonstrates the significance of development mechanism of age-related cataract consequent to the loss of barrier properties of the lens capsule based on analysis of the accumulation of sodium, calcium, phosphorus and potassium. Spatial cluster analysis and correlation analysis were used to reveal for the first time the relation between the diffusion of light in the body of the crystalline lens and changes in its elemental composition. Distribution fields of elevated concentrations of sodium, calcium, phosphorus, potassium and chlorine are consistent with geometry of the lens capsule and clusterize together with areas of opacification in its body. The accumulation geometry of the elements in the lens body is also commonly seen in the aqueous humor of the anterior chamber, which can be considered evidence for excessive transitioning of their compounds through the lens capsule shell, while spatial connection with transparency changes - proof of its participation in cataractogenesis.
About the authors
N. A. Pakhomova
Research Institute of Eye Diseases
Email: i.novikov@niigb.ru
Russian Federation, 11A, Rossolimo street, Moscow, 119021
T. E. Borisenko
Research Institute of Eye Diseases
Email: i.novikov@niigb.ru
Russian Federation, 11A, Rossolimo street, Moscow, 119021
I. A. Novikov
Research Institute of Eye Diseases
Author for correspondence.
Email: i.novikov@niigb.ru
Russian Federation, 11A, Rossolimo street, Moscow, 119021
S. E. Avetisov
Research Institute of Eye Diseases; The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation
Email: i.novikov@niigb.ru
Academician of the Russian Academy of Sciences
Russian Federation, 11A, Rossolimo street, Moscow, 119021; 8-2, Trubetskaya street, Moscow, 119992References
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