Email this article New positive allosteric modulator of AMPA-receptors: in vitro and in vivo studies
- Authors: Grigoriev V.V.1, Lavrov M.I.1,2, Zamoyski V.L.1, Garibova T.L.3, Palyulin V.A.1,2, Bachurin S.O.1
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Affiliations:
- Institute of Physiologically Active Substances of the Russian Academy of Sciences
- Lomonosov Moscow State University
- State Foundation Institute of Pharmacology of the Russian Academy of Medical Sciences
- Issue: Vol 488, No 2 (2019)
- Pages: 217-220
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/16112
- DOI: https://doi.org/10.31857/S0869-56524882217-220
- ID: 16112
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Abstract
A new derivative of 3,7-diazabicyclo[3.3.1]nonane was studied in electrophysiological experiments, which showed high activity as a positive allosteric modulator of AMPA receptors of the CNS. In doses of 0.01 mg/kg this compound significantly improved the memory of experimental animals disturbed by maximal electric shock. The results indicate that this compound is a promising candidate for preclinical and clinical studies as a treatment for a number of psycho-neurological diseases.
About the authors
V. V. Grigoriev
Institute of Physiologically Active Substances of the Russian Academy of Sciences
Email: vzam@yandex.ru
Russian Federation, 1, Severny passage, Chernogolovka, Moscow region, 142432
M. I. Lavrov
Institute of Physiologically Active Substances of the Russian Academy of Sciences; Lomonosov Moscow State University
Email: vzam@yandex.ru
Russian Federation, 1, Severny passage, Chernogolovka, Moscow region, 142432; 1, Leninskie gory, Moscow, 119991
V. L. Zamoyski
Institute of Physiologically Active Substances of the Russian Academy of Sciences
Author for correspondence.
Email: vzam@yandex.ru
Russian Federation, 1, Severny passage, Chernogolovka, Moscow region, 142432
T. L. Garibova
State Foundation Institute of Pharmacology of the Russian Academy of Medical Sciences
Email: vzam@yandex.ru
Russian Federation, 8, Baltiyskaya street, Moscow, 125315
V. A. Palyulin
Institute of Physiologically Active Substances of the Russian Academy of Sciences; Lomonosov Moscow State University
Email: vzam@yandex.ru
Russian Federation, 1, Severny passage, Chernogolovka, Moscow region, 142432; 1, Leninskie gory, Moscow, 119991
S. O. Bachurin
Institute of Physiologically Active Substances of the Russian Academy of Sciences
Email: vzam@yandex.ru
Сorresponding Member of Russian Academy of Sciences
Russian Federation, 1, Severny passage, Chernogolovka, Moscow region, 142432References
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