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Effect of fabomotizole on brain gene expression in MR rats upon open field test
- Authors: Vakhitova Y.V.1, Kuzmina U.S.2, Voronin M.V.1, Zainullina L.F.1, Seredenin S.B.1
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Affiliations:
- Institute of Pharmacology of the Russian Academy of Medical Sciences
- Institute of Biochemistry and Genetics, Subdivizion of the Ufa Federal Research Centre of the Russian Academy of Science
- Issue: Vol 488, No 3 (2019)
- Pages: 329-332
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/16275
- DOI: https://doi.org/10.31857/S0869-56524883329-332
- ID: 16275
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Abstract
Selective anxiolytic fabomotisol (Afobazol®) has affinity for the Sigma-1 chaperone receptor site, quinone reductase 2 (NQO2) and MAO-A regulatory sites, and melatonin receptor type 1 (MT1 receptor). The analysis of the effect of fabomotisol on the gene expression profile in the brain of MR (Maudsley Reactive) rats was carried out when modeling emotional stress in the open field test. A change in the expression of 14 genes was found, the results of the functional annotation of which show that the mechanisms of action of fabomotisol may be associated with the regulation of translation of proteins (Rpl5, Rpl15, Ncl, Ybx1), synaptic functions (Cplx2, Dlg4, Syngap1, Add1, Rab8b, Klc1, Chn1) and cellular metabolism (Akr1d1, Bcat1, Pkm).
About the authors
Yu. V. Vakhitova
Institute of Pharmacology of the Russian Academy of Medical Sciences
Author for correspondence.
Email: juvv73@gmail.com
Russian Federation, 8, Baltiyskaya street, Moscow, 125315
U. Sh. Kuzmina
Institute of Biochemistry and Genetics, Subdivizion of the Ufa Federal Research Centre of the Russian Academy of Science
Email: juvv73@gmail.com
Russian Federation, 71, October prospect, Ufa, 450054
M. V. Voronin
Institute of Pharmacology of the Russian Academy of Medical Sciences
Email: juvv73@gmail.com
Russian Federation, 8, Baltiyskaya street, Moscow, 125315
L. F. Zainullina
Institute of Pharmacology of the Russian Academy of Medical Sciences
Email: juvv73@gmail.com
Russian Federation, 8, Baltiyskaya street, Moscow, 125315
S. B. Seredenin
Institute of Pharmacology of the Russian Academy of Medical Sciences
Email: juvv73@gmail.com
Academician of the Russian Academy of Science
Russian Federation, 8, Baltiyskaya street, Moscow, 125315References
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