Email this article Histone tails promote PARP1-dependent structural rearrangements in nucleosomes
- Authors: Maluchenko N.V.1, Sultanov D.S.2, Kotova E.Y.2, Kirpichnikov M.P.1,3, Studitsky V.M.1,2, Feofanov A.V.1,3
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Affiliations:
- Lomonosov Moscow State University
- Fox Chase Cancer Center
- Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
- Issue: Vol 489, No 3 (2019)
- Pages: 318-320
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/18603
- DOI: https://doi.org/10.31857/S0869-56524893318-320
- ID: 18603
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Abstract
PARP1 alters the wrapping of nucleosomal DNA on the surface of the histone octamer, thereby modulating the accessibility of different genome sites to nuclear protein factors. Here we show that non-structured histone tails participate in the PARP1-induced structural rearrangements in nucleosomes, facilitate and stabilize them, but do not affect the enzymatic activity of PARP1.
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About the authors
N. V. Maluchenko
Lomonosov Moscow State University
Author for correspondence.
Email: mal_nat@mail.ru
Russian Federation, 1, Leninskie gory, Moscow, 119991
D. S. Sultanov
Fox Chase Cancer Center
Email: mal_nat@mail.ru
United States, 333, Cottman Ave, Philadelphia, Pennsylvania, 19111
E. Yu. Kotova
Fox Chase Cancer Center
Email: mal_nat@mail.ru
United States, 333, Cottman Ave, Philadelphia, Pennsylvania, 19111
M. P. Kirpichnikov
Lomonosov Moscow State University; Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: mal_nat@mail.ru
Academician of the Russian Academy of Sciences
Russian Federation, 1, Leninskie gory, Moscow, 119991; 16/10, Miklukho-Maklaya street, Moscow, 117997V. M. Studitsky
Lomonosov Moscow State University; Fox Chase Cancer Center
Email: mal_nat@mail.ru
Russian Federation, 1, Leninskie gory, Moscow, 119991; 333, Cottman Ave, Philadelphia, Pennsylvania, USA, 19111
A. V. Feofanov
Lomonosov Moscow State University;Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: mal_nat@mail.ru
Russian Federation, 1, Leninskie gory, Moscow, 119991; 16/10, Miklukho-Maklaya street, Moscow, 117997
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