Morphologic Substantiation of Distraction as a Preparatory Step for Bioactive Interphalangeal Hand Joint Arthroplasty in Fibrous Ankylosis


The work is dedicated to the study of the morphologic peculiarities of proximal interphalangeal joint capsule before and after distraction in order to substantiate the use of distraction technique as a preparatory step for proximal interphalangeal hand joints bioactive arthroplasty in fibrous ankylosis. The study was conducted on the samples of small fragments of proximal interphalangeal hand joint capsule (11 patients) before distraction and 2 months after distraction apparatus removal. Control group (conventional norm) was presented by 6 autopsy samples. Light microscopy using standard staining methods and immunohistochemical examination were performed. Activation of angiogenesis processes, i.e. 3.5 times increase of vascular bed, 3.4 times growth of mature labrocytes number, both partially and maximum degranulated, as compared with the nondistracted tissue and control group. Direct correlation between the growth of mature labrocytes number and fibroblasts, and the quantity of newly formed vessels per unit of tissue area was detected. Distraction enables to raise the vitality and resistance of pathologically changed joint tissues to damaging factors (hypoxia), activates functional status of joint surrounding tissues and could be considered as a preparatory step for fibrotically ankylosed interphalangeal hand joints bioactive arthroplasty.

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S. N Bugrov

Privolzhsky Federal Medical Research Centre

Nizhny Novgorod, Russia

D. V Davydenko

Privolzhsky Federal Medical Research Centre

Nizhny Novgorod, Russia

N. Yu Shirokova

Privolzhsky Federal Medical Research Centre

Nizhny Novgorod, Russia

A. V Novikov

Privolzhsky Federal Medical Research Centre

Nizhny Novgorod, Russia

S. V Petrov

Privolzhsky Federal Medical Research Centre

Nizhny Novgorod, Russia


  1. Матвеев Р.П., Петрушин А.Л. Вопросы классификации и терминологии открытых повреждений кисти. Травматология и ортопедия России. 2011; 2 (60): 191-8.
  2. Науменко Л.Ю., Маметьев А.А. Современные аспекты лечения больных с посттравматическими дефектами и деформациями суставов пальцев кисти. Травма. 2012; 13 (3): 109-12.
  3. Houshian S., Chikkamuniyappa C. Distraction correction of chronic flexion contractures of PIP joint: comparison between two distraction rates. J. Hand Surg. 2007; 32A: 651-56.
  4. Ланцов Ю.А., Маланин Д.А. Восстановление функции суставов пальцев кисти: реальность и перспективы. Волгоградский научно-медицинский журнал. 2007; 1: 49-51.
  5. Heard B.E., Dewar A., Corrin B. Apposition of fibroblasts to mast cells and lymphocytes in normal human lung and in cryptogenic fibrosing alveolitis. Ultrastructure and cell perimeter measurements. J. Pathol. 1992; 166: 303.
  6. Hildebrand K.A., Zhang M., Hart D.A. High rate of joint capsule matrix turnover in chronic human elbow contractures. Clin. Orthop. Relat. Res. 2005; 439: 228-334.
  7. Ilizarov G.A. The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. Clin. Orthop. Relat. Res. 1989; (238): 249-81.
  8. Ilizarov G.A. The tension-stress effect on the genesis and growth of tissues: part II. The influence of the rate and frequency of distraction. Clin. Orthop. Relat. Res. 1989; (239): 263-85.
  9. Jaalouk D.E., Lammerding J. Mechanotransduction gone awry. Nature Reviews Molecular Cell Biology. 2009; 10: 63-73.
  10. Makhdom A.M., Nayef L., Tabrizian M., Hamdy R.C. The potential roles of nanobiomaterials in distraction osteogenesis. Nanomedicine. 2015; 1 (11): 1-18.
  11. Шевцов В.И., Ирьянов Ю.М. Влияние дистракции на репаративный остеогенез. Гений ортопедии. 1998; 4: 12-24.
  12. Makarov M., Birch J., Samchukov M. The role of variable muscle adaptation to limb lengthening in the development of joint contractures: an experimental study in the goat. J. Pediatr. Orthop. 2009; 29: 175-81.
  13. Gillard G.C., Reilly H.C., Bell-Booth P.G., Flint M.H. A comparison of the glycosaminoglycans of weight-bearing and non-weight-bearing human dermis. J. Invest. Dermatol. 1977; 69: 257-61.
  14. Gillard G.C., Merrilees M.J., Bell-Booth P.G., Reilly H.C., Flint M.H. The proteoglycan content and the axial periodicity of collagen in tendon. Biochem. J. 1977; 163: 145-51.
  15. Parkkinen J.J., Lammi M.J., Helminen H.J., Tammi M. Local stimulation of proteoglycan synthesis in articular cartilage explants by dynamic compression in vitro. J. Orthop. Res. 1992; 10: 610-20.
  16. Watanabe M., Nojima M., Shibata T., Hamada M. Maturation-related biochemical changes in swine anterior cruciate ligament and tibialis posterior tendon. J. Orthop. Res.1994; 12: 672-82.
  17. Надеин К.А. Тучные клетки как фактор развития воспалительных процессов в соединительной ткани. Обзоры по клинической фармакологии и лекарственной терапии. 2012; 10 (1): 22-7.
  18. Monument M.J., Hart D.A., Salo P.T., Befus A.D., Hildebrand K.A. Neuroinflammatory mechanisms of connective tissue fibrosis: targeting neurogenic and mast cell contributions. Аdvances in wound care. 2013; 4 (3): 137-51.
  19. Тер-Асатуртов Г.П., Рябов А.Ю., Лекишвили М.В., Юрасова Ю.Б. Экспериментальная сравнительная оценка некоторых биоматериалов, используемых в российской челюстно-лицевой хирургии. Российский стоматологический журнал. 2009; 4: 11-3.
  20. Добрынина И.В., Тельцов Л.П., Музыка И.Г. Полисахариды клеток соединительной ткани стенки двенадцатиперстной кишки эмбрионов человека. Вестник новых медицинских технологий. Электронный журнал. 2014; 1: 138. URL: (дата обращения: 25.12.2014).



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Copyright (c) 2016 Bugrov S.N., Davydenko D.V., Shirokova N.Y., Novikov A.V., Petrov S.V.

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