Elaboration of New Treatment Methods for Spinal Cord Injuries Using Magnetic Nanoparticles in Combination with Electromagnetic Field (Experimental Study)

Abstract


The latest studies on the use of magnetic nanoparticles (MNP) in biological systems prove their high biocompatibility and possibility to interact with various types of cells including the neurons. This may serve as a basis for potential restoration of the neuronal network after nerve tissue integrity damage. The purpose of the study was to determine the influence of MNP on the restoration of hind paws function in experimental animals after spinal cord transection (by 50, 80 and 100%) under the influence of a magnetic field. Magnetic nanoparticles were inserted into the injury zone via plastic catheter. The degree of function loss and its subsequent restoration was assessed by BBB Locomotor Scale and induced potentials on the first postoperative day and then weekly within one month. Statistically significant (p<0.001) increase of both the induced potentials’ amplitude and mean functional indices was reordered only in group with 50% spinal cord transection. Also in that group the less marked scar changes and the highest neuronal cells survival rate was observed. Use of MNP under the influence of external magnetic field promotes the restoration of motor function and increases the conductivity of injured spinal cord tissues in experimental animals in the mean long term period. The mechanism of such restoration needs further study.

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About the authors

S. V Kolesov

N.N. Priorov Central Institute of Traumatology and Orthopaedics

Moscow, Russia

A. A Panteleev

N.N. Priorov Central Institute of Traumatology and Orthopaedics

Moscow, Russia

M. L Sazhnev

N.N. Priorov Central Institute of Traumatology and Orthopaedics

Email: mak.sajnev@yandex.ru
Moscow, Russia

A. I Kaz’min

N.N. Priorov Central Institute of Traumatology and Orthopaedics

Moscow, Russia

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Copyright (c) 2016 Kolesov S.V., Panteleev A.A., Sazhnev M.L., Kaz’min A.I.

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