Comparative Study of Certain Serum Markers in Experimental Osteosynthesis Using Implants with Titanium Nitride and Hafnium Coating


Simulation of intramedullary osteosynthesis was performed at experimental tibia fracture in 30 rabbits, 6-7 months aged. In main group pins from medical steel coated by mixture of titanium nitride and hafnium were used, in comparative group pins without coating were used. Comparative study of certain biochemical blood indices, P and Ca content was performed. It was shown that application of implants coated by titanium nitride and hafnium that possessed high firmness and chemical stability did not cause additional reactive changes in experimental animals as compared with implants of medical steel. It confirmed the prospects of bioinert titanium nitride and hafnium coated nanotechnologic implants application for prevention of possible individual intolerance of metals.

Full Text

Сравнительное изучение ряда сывороточных маркеров при экспериментальном остеосинтезе имплантатами с покрытием нитридами титана и гафния


  1. Sovak G., Weiss A., Gotman I. Osseointegration of Ti6Al4V alloy implants coated with titanium nitride by a new method. J. Bone Joint Surg. Br. 2000; 82 (2): 290-6.
  2. Yao Chen, Tapas Laha, Kantesh Balani, Arvind Agarwal. Nanomechanical properties of hafnium nitride coating. Scripta Materialia. 2008; 58: 1121-4.
  3. Абдуллин И.Ш., Миронов М.М., Гарипова Г.И. Бактерицидные и биологически стойкие покрытия для медицинских имплантатов и инструментов. Медицинская техника. 2004; 4: 20-2.
  4. Ахтямов И.Ф., Гатина Э.Б., Шакирова Ф.В., Кадыров Ф.Ф. и др. Изучение костной ткани и имплантатов с покрытиями из нитритов титана и гафния на остеорегенерацию с использованием рентгенографических исследований. Вестник Казанского технологического университета. 2012; 15 (20): 186-7.
  5. Paskalev M., Krastev S., Filipov J. Changes in some serum markers after experimental fracture and intramedullary osteosynthesis in dogs. Trakia J. Sciences. 2005; 3 (5): 46-50.
  6. Akesson K., Kakonen S.M., Josefsson P.O., Karlsson M.K., Obrant K.J., Petersson K. Fracture-induced changes in bone turnover: a potential confounder in the use of biochemical markers in оsteoporosis. J. Bone Miner. Metab. 2005; 23 (1): 30-5.
  7. Sato Y., Kaji M., Higuchi F., Yanagida I., Oishi K., Oizumi K. Changes in bone and calcium metabolism following hip fracture in elderly patients. Osteoporos Int. 2001; 12 (6): 445-9.
  8. Tobita K., Ohnishi I., Matsumoto T., Ohashi S., Bessho M., Kaneko M., Nakamura K. Measurement of mechanical properties on gap healing in a rabbit osteotomy model until the remodeling stage. Clin. Biomech. (Bristol, Avon). 2012; 27 (1): 99-104.
  9. Руднов В.А. Клиническая значимость и возможные пути коррекции гипергликемии при критических состояниях. Consilium medicum. 2006; 8 (7): 54-61.
  10. Connolly C.C., Steiner K.E., Stevenson R.W., Neal D.W., Williams P.E., Alberti K.G., Cherrington A.D. Regulation of lipolysis and ketogeneis by norepinephrine in conscious dogs. Am. J. Phisiol. 1991; 261 (4 Pt 1): E466-72.



Abstract - 27


Article Metrics

Metrics Loading ...


  • There are currently no refbacks.

Copyright (c) 2013 Eco-Vector

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies