Efficacy of Tranexamic Acid Application for Blood Loss Reduction in Total Hip Arthroplasty



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Abstract

Prospective study of tranexamic acid use results (native preparation Tranexam) in primary total hip arthroplasty was performed during the period from March to October 2009. The study involved 159 patients (55 men, 104 women) with various hip joint pathology (79 patients - main group, 80 patients - control group). Mean age of patients made up 55.7 years (17 - 80 years). In patients from the main group 15 mg/kg Tranexam was injected just prior to operation with reinjection of the same dose in 6 hours. In control group etamsylate (750 mg 30 minutes prior to incision with reintroduction in 4 - 6 hours, daily dose up to 1500 mg) was applied. The results of the analysis showed reliable (p<0.001) decrease of total blood loss in the main group (409±228 ml) as compared to the control group (638±437 ml). The reasonability of the use of tranexamic acid for reduction of blood loss in total hip arthroplasty was shown.

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