Modeling of Posttraumatic Changes in Knee Joint in Animal Experiments
- Authors: Mironov SP1, Omel'yanenko NP1, Trotsenko VV1, Karpov IN1, Kurpyakov A.P.1, Mironov SP1, Omel'yanenko NP1, Trotsenko VV1, Karpov IN1, Kurpyakov AP1
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Affiliations:
- Issue: Vol 16, No 4 (2009)
- Pages: 3-12
- Section: Articles
- Submitted: 20.10.2020
- Published: 15.12.2009
- URL: https://journals.eco-vector.com/0869-8678/article/view/48003
- DOI: https://doi.org/10.17816/vto20091643-12
- ID: 48003
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Abstract
6 months after operation using narcosis overdosage. The obtained data were analyzed by anatomic- morphologic and histochemical methods. Formed posttraumatic structures in the articular cartilage and subchondral bone are constant and may be considered as signs of deforming arthrosis. According to the depth of injury and morphologic changes in the involved cartilaginous and bone articular tissues three degrees of osteoarthrosis are marked out. In every degree the injured joint may be used as a model for the choice of adequate therapy.
Keywords
About the authors
S P Mironov
N P Omel'yanenko
V V Trotsenko
I N Karpov
Anton Pavlovich Kurpyakov
Email: kurpyakov@mail.ru
S P Mironov
N P Omel'yanenko
V V Trotsenko
I N Karpov
A P Kurpyakov
References
- Купчинов Б.И., Ермаков С.Ф., Белоенко Е.Д. Биотрибология синовиальных суставов. - Минск, 1997.
- Лаврищева Г.И., Оноприенко Г.А. Морфологические и клинические аспекты репаративной регенерации опорных органов и тканей. - М., 1996.
- Миронов С.П., Омельяненко Н.П., Орлецкий А.К. и др. Остеоартроз: современное состояние проблемы //Вестн. травматол. ортопед. - 2001. - N 2. - С. 96-99.
- Павлова М.В. Синовиальная среда сустава. - М., 1980.
- Панков Е.Я., Фелдыш И., Дедух Н.В. и др. Сравнительное морфологическое изучение различных моделей деформирующего артроза //Ортопед. травматол. - 1988. - N 6. - С. 61-70.
- Слуцкий Л.И. Биохимия нормальной и патологически измененной соединительной ткани. - Л., 1969.
- Adams M.E., Brandt K.D. Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection //J. Rheumatol. - 1991. - Vol. 18, N 3. - P. 428-435.
- Altman R.D. Design and conduct of clinical trials in osteoarthrosis //Scand. J. Rheumatol. - 1990. - Suppl. 81. - P. 24-27.
- Armstrong S.J., Read R.A., Price R. Topographical va-riation within the articular cartilage and subchondral bone of the normal ovine knee joint: a histological approach //Osteoarthritis Cartilage. - 1995. - N 3. - P. 25-33.
- Boni M., Lenzi L., Berlanda P. et al. Experimental arthrosis from intraarticular vitamin A injection in the rabbit. Morphological study; considerations on the pathogenesis of human arthrosis in relation to the experimental model //Ital. Orhop. Traumatol. - 1977. - Vol. 111, N 1. - P. 5-26.
- Brandt K.D. Animal models of osteoarthritis //Biorheo-logy. - 2002. - Vol. 39, N 1-2. - P. 221-235.
- Brandt K.D., Braunstein E.M., Visco D.M. et al. Anterior (cranial) cruciate ligament transection in the dog: a bona fide model of osteoarthritis, not merely of cartilage injury and repair //J. Rheumatol. - 1991. - Vol. 18, N 3. - P. 436-446.
- Brandt K.D., Smith G.N., Myers SL. Hyaluronan injection affects neither osteoarthritis progression nor loa-ding of the OA knee in dogs //Biorheology. - 2004. - Vol. 41, N 3-4. - P. 493-502.
- Brittberg M., Sjцgren-Jansson E., Lindahl A., Peterson L. Influence of fibrin sealant (Tisseel) on osteochond- ral defect repair in the rabbit knee //Biomaterials. - 1997. - Vol. 18, N 3. - P. 235-242.
- Chu C.R., Dounchis J.S., Yoshioka M. et al. Osteochond-ral repair using perichondrial cells. A 1-year study in rabbits //Clin. Orthop. - 1997. - N 340. - P. 220-229.
- Ghosh P., Holbert C., Read R., Armstrong S. Hyaluro-nic acid (hyaluronan) in experimental osteoarthritis //J. Rheumatol. - 1995. - Vol. 43, N 2. - P. 155-157.
- Hurtig M.B, Novak K., McPherson R. et al. Osteochond-ral dowel transplantation for repair of focal defects in the knee: an outcome study using an ovine model //Ve-terinary Surg. - 1998. - Vol. 27. - P. 5-16.
- Little C.B., Ghosh P., Bellenger C.R. Topographic variation in biglycan and decorin synthesis by articular cartilage in the early stages of osteoarthritis: an experimental study in sheep //J. Orthop. Res. - 1996. - Vol. 14, N 3. - P. 433-444.
- Lozada C.J., Altman R.D. Animals models of cartilage breakdown //Bone and Cartilage Metabolism /Eds. M.J. Seibel, S.P. Robins, J.P. Bilezikian. - San Diego, 1999. - P. 339-352.
- McDevitt C.A. Biochemistry of articular cartilage. Nature of proteoglycans and collagen of articular cartilage and their role in ageing and in osteoarthro- sis //Ann. Rheum. Dis. - 1973. - Vol. 32, N 4. - P. 364-378.
- Moskowitz P.W., Davis I.V., Sammarco J. et al. Experimentally-induced degenerative joint lesions following partial meniscotomy in the rabbit //Arthritis Rheum. - 1973. - 16. - P. 397-405.
- Pomonis J.D., Boulet J.M., Gottshall S.L. et al. Development and pharmacological characterization of a rat model of osteoarthritis pain //Pain. - 2005. - Vol. 114, N 3. - P. 339-346.
- Pond M.J., Nuki G. Experimentally-induced ostheoarthntis in the dog //Ann. Rheum. Dis. - 1973. - Vol. 32. - P. 387-388.
- Salter R.B., Gross A., Hall J.H. Hydrocortisone art-ropathy - an experimental investigation //Canad. Med. Assoc. J. - 1967. - Vol. 97, N 8. - P. 374-377.
- Schwarz R. Animal models: a means to study the рathogenesis of оsteoarthritis //J. Rheum. - 1987. - Vol. 14. - P. 101-103.
- Smith M.M., Cake M.A., Ghosh P. et al. Significant synovial pathology in a meniscectomy model of os-teoarthritis: modification by intra-articular hyaluronan therapy //Rheumatology (Oxford). - 2008. - Vol. 47, N 8. - P. 1172-1178.
- Vignon E., Arlot M., Hartmann D. et al. Hypertrophic repair of articular cartilage in experimental osteoarthrosis //Ann. Rheum. Dis. - 1983. - Vol. 42, N 1. - P. 82-88.
- Wakitani S., Imoto K., Kimura T. et al. Hepatocytegrowth factor facilitates cartilage repair. Full thickness articular cartilage defect studied in rabbit knees /Acta Orthop. Scand. - 1997. - Vol. 68, N 5. - P. 474-480.