Radionuclid Scintigraphy for the Control Reparative Processes in Bone Irradiated Replants

Abstract


The remodeling of irradiated bone re-implant placed into simultaneously irradiated bed was studied by scintigraphy method using 99Tc-labeled drug (TcLD) (perfoteh). The data obtained were compared with data of radiologic control. The study included 11 patients with osteogenic sarcoma who were operated on after chemo -radiotherapy course. The peculiarities of operation were as follows. Resected bone with tumor was irradiated by single 60 G dose, after that the bone was re-implanted. It was revealed that 1 month postoperatively TcLD retention in contact zone of bone fragments was 2-2.5 times higher as compared with the symmetric zone of healthy bone. Remodeling peak was observed 1.5-2 months after operation. Over that interval TcLD retention decreased gradually and by 18 months the contact zone was not detected on scintigrams. According to the data of radiologic control the peak of remodeling took place at 6-8 months after operation. The study showed that irradiated re-implant preserved mechanical stiffness and worked as a biologic prosthesis while substituting the newly formed bone. Scintigraphy is an additional method the earlier assessment of reparative processes in extracorporal irradiated reimplant as compared to the assessment of radiologic control.

References

  1. Бардычев М.С., Цыб А.Ф. Местные лучевые повреждения. - М., 1985.
  2. Березовская Т.П. Радионуклидное изучение репаративного костеобразования и кровообращения при чрескостном компрессионно-дистракционном остеосинтезе по Г.А. Илизарову в условиях гнойной инфекции: Автореф. дис. ... канд. мед. наук. - М., 1988.
  3. Ведзижев Г.М., Испенков Е.А., Перехрест М.А. //Радионуклидные препараты для радиоизотопной диагностики: Сб. науч. работ. - Обнинск, 1979. - С. 15-18.
  4. Ведзижев Г.М. Испенков Е.А., Дроздовский Б.Я., Перехрест М.А. //Мед. радиол. - 1985. - N 11. - С. 12-16.
  5. Гладкова Г.С. //Проблемы пересадки и консервации органов и тканей. - М., 1959. - С. 223-225.
  6. Зацепин СТ. Сохранные операции при опухолях костей. - М., 1984.
  7. Испенков Е.А. Радиоизотопные методы исследования в диагностике опухолей и некоторых других заболеваний костей: Автореф. дис. ... канд. мед. наук. - М., 1974.
  8. Испенков Е.А., Габуния Р.И., Перехрест М.А. и др. //Стандартизированные методики радиоизотопной диагностики: Метод, рекомендации. - Обнинск, 1987. - С. 301-310,
  9. Касаткин Ю.Н., Пурижанский И.М., Сурвила З.П. и др. //Мед. радиол. - 1976. - N 10. - С. 59-66.
  10. Лаврищева Г.И. //Проблемы пересадки и консервации органов и тканей. - М., 1959. - С. 225-226.
  11. Радиоизотопная диагностика метастатического поражения костей с помощью пирофосфата олова 99тТс: Метод, рекомендации. - Обнинск, 1981. - С. 25.
  12. Урбаж В.Ю. Биометрические методы. - М., 1964.
  13. Rosen G., Marcove R.C., Caparros В. et al. //Cancer (Philad). - 1979. - Vol. 43. - P. 2163-2177.
  14. Russe D.-L. //Allgemeinmed. - 1982. - Bd 58. - S. 1569-1573.
  15. Yadav S.S. //Indian J. Cancer. - 1981. - Vol. 18. - P. 206-210.

Statistics

Views

Abstract - 18

Cited-By


Article Metrics

Metrics Loading ...

Refbacks

  • There are currently no refbacks.

Copyright (c) 2003 Eco-Vector



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies