Local antibacterial depot systems in the treatment of bone and joint infection (review)

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Abstract

Local depot systems with high antibiotic content are an essential component of combination therapy in osteoarticular infections. These systems are effective against microbial biofilms by providing drug concentrations that surpass the requirements of planktonic bacteria. Currently, there are numerous support matrixes with various properties. Only a few of them are sufficiently studied and actively used in clinical practice. These include polymethylmethacrylate-based bone cement, calcium sulfate, collagen, allografts, etc. However, the vast majority of local systems have only been studied in vitro and in vivo. This review describes currently available depot systems, including their primary properties, advantages, and disadvantages, as well as potential for future use of a specific matrix both for the treatment and prevention of diseases.

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About the authors

Regina E. Melikova

Priorov Central Research Institute of Traumatology and Orthopedics

Email: regina-melikova@mail.ru
ORCID iD: 0000-0002-5283-7078
SPIN-code: 8288-0256

MD, Cand. Sci. (Medicine)

Russian Federation, 10 Priorova str., 127299 Moscow

Archil V. Tsiskarashvili

Priorov Central Research Institute of Traumatology and Orthopedics

Author for correspondence.
Email: armed05@mail.ru
ORCID iD: 0000-0003-1721-282X
SPIN-code: 2312-1002

MD, Cand. Sci. (Medicine)

Russian Federation, 10 Priorova str., 127299 Moscow

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