Results of microbiological monitoring of leading patients in infected fractures of long bones under conditions of external osteosynthesis



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Background: The etiology of fracture-related infections (FRI) is caused by microbes, the spectrum of which can vary greatly in different clinics. The leading pathogens are usually Staphylococcus aureus and coagulase-negative staphylococci, to a lesser extent — Gram-negative microbes, anaerobes and fungi.

Aim: To identify the leading pathogens and their dynamics in patients with FRI of long bones treated with transosseous osteosynthesis in the period 2019–2024.

Materials and methods: The results of cultures of 247 patients with FRI and chronic osteomyelitis as its consequence, treated by the method of transosseous osteosynthesis in our department were retrospectively studied. The spectrum of leading pathogens and their dynamics by time periods were studied. Statistical data were processed by the Pearson χ2 criterion.

Results: Positive growth was obtained in 70.4% of patients, negative — in 29.6%. A total of 230 microorganisms were identified: gram-positive — 158 (68.7%), gram-negative — 71 (30.9%), fungi — 1 (0.4%). Monomicrobial infection was detected in 76.4% of cases, polymicrobial — in 23.6%. In 18.4% of observations, a change of microbes was noted: 15.5% — during treatment, 2.9% — during relapse.

Conclusion: Despite the increase in the proportion of MRSE, E. faecalis, Corynebacterium, K. pneumoniae and E. cloacae in the structure of FRI, the leading pathogen remains S. aureus.

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作者简介

Archil Tsiskarashvili

Federal State Budgetary Institution "National Medical Research Center of Traumatology and Orthopedics named after N.N. Priorov" of the Ministry of Health of the Russian Federation

Email: armed05@mail.ru
ORCID iD: 0000-0003-1721-282X
SPIN 代码: 2312-1002

Заведующий отделением последствий травм опорно-двигательной системы и гнойных осложнений № 5,
врач-травматолог-ортопед высшей квалификационной категории,
кандидат медицинских наук

俄罗斯联邦

Regina Melikova

Priorov Central Research Institute of Traumatology and Orthopedics

Email: regina-melikova@mail.ru
ORCID iD: 0000-0002-5283-7078
SPIN 代码: 8288-0256

MD, Cand. Sci. (Medicine)

俄罗斯联邦, 10 Priorova str., 127299 Moscow

Anton Nazarenko

Национальный медицинский исследовательский центр травматологии и ортопедии имени Н.Н. Приорова, Москва, Россия

编辑信件的主要联系方式.
Email: nazarenkoag@cito-priorov.ru

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