Chemotherapy-induced peripheral polyneuropathy in breast cancer patients
- Authors: Karpov S.M.1, Tambieva K.K.1, Klimenko A.I.1, Vyshlova I.A.1, Koychuev A.A.1, Minin A.V.1
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Affiliations:
- Stavropol State Medical University
- Issue: Vol LVI, No 4 (2024)
- Pages: 403-410
- Section: Reviews
- Submitted: 13.03.2024
- Accepted: 11.09.2024
- Published: 19.12.2024
- URL: https://journals.eco-vector.com/1027-4898/article/view/629040
- DOI: https://doi.org/10.17816/nb629040
- ID: 629040
Cite item
Abstract
Breast cancer is the second most common cancer overall, the most common cancer in women, and a leading cause of death in women. The incidence of brain metastases has increased due to longer patient survival. Thus, chemotherapy for breast cancer has significantly increased promising a positive outcome. However, long-term and repeated chemotherapy leads to involvement of the peripheral nervous system by creating clinical issues dominated by peripheral neuropathy and cognitive changes.
This literature review assesses the negative neurological effects of chemotherapy in breast cancer patients.
The review discusses neuropathic pain mechanisms, primarily neuroimmune and inflammatory changes, ion-channel remodeling, mitochondrial dysfunction, and genetic predisposition. The review gives advice on the prevention of peripheral neuropathy and neuropathic pain in breast cancer patients. It shows the relationship of chemotherapy and deteriorated quality of life, where special attention should be paid to early detection and treatment of chemotherapy-induced peripheral polyneuropathy to improve the quality of life of breast cancer patients.
With advances in pharmacology, the introduction of targeted therapy and its combinations, especially those involving epidermal growth factor receptor 2, the survival potential of breast cancer patients increases, but there are risks of more frequent neurological complications, primarily peripheral neuropathy and cognitive changes.
Keywords
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About the authors
Sergey M. Karpov
Stavropol State Medical University
Email: karpov25@rambler.ru
ORCID iD: 0000-0003-1472-6024
SPIN-code: 3890-9809
MD, Dr. Sci. (Medicine), Professor, Head of the Department of Neurology, Neurosurgery and Medical Genetics
Russian Federation, StavropolKhava K.-S. Tambieva
Stavropol State Medical University
Email: khavatam@icloud.com
ORCID iD: 0000-0001-7884-2767
postgraduate student of the Department of Neurology, Neurosurgery and Medical Genetics
Russian Federation, StavropolAnna I. Klimenko
Stavropol State Medical University
Email: anyutikkovalenko@mail.ru
ORCID iD: 0000-0002-2201-7626
SPIN-code: 1736-0048
neurologist
Russian Federation, StavropolIrina A. Vyshlova
Stavropol State Medical University
Author for correspondence.
Email: irisha2801@yandex.ru
ORCID iD: 0000-0001-9187-8481
SPIN-code: 6908-7872
MD, Dr. Sci. (Medicine), Associate Professor of the Department of Neurology, Neurosurgery and Medical Genetics
Russian Federation, StavropolArsen A. Koychuev
Stavropol State Medical University
Email: onco_stgmu@mail.ru
ORCID iD: 0000-0003-2856-1056
SPIN-code: 2196-6568
MD, Dr. Sci. (Medicine), Professor, Head of the Department of Oncology and Radiation Therapy
Russian Federation, StavropolAlexander V. Minin
Stavropol State Medical University
Email: aleksanderminin2016@yandex.ru
ORCID iD: 0009-0001-5054-1601
oncologist surgeon
Russian Federation, StavropolReferences
- Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359-386. doi: 10.1002/ijc.29210
- Chew S, Carroll HK, Darwish W, et al. Characterization of treatments and disease course for women with breast cancer brain metastases: 5-year retrospective single institution experience. Cancer Manag Res. 2021;13:8191–8198. doi: 10.2147/CMAR.S330829
- Kim HJ, Im SA, Keam B, et al. Clinical outcome of central nervous system metastases from breast cancer: differences in survival depending on systemic treatment. J Neurooncol. 2012;106(2):303–313. doi: 10.1007/s11060-011-0664-8
- Avila J, Leone JP. Advances in the management of central nervous system metastases from breast cancer. Int J Mol Sci. 2022;23(20):12525. doi: 10.3390/ijms232012525
- Mustafa Ali M, Moeller M, Rybicki L, et al. Long-term peripheral neuropathy symptoms in breast cancer survivors. Breast Cancer Res Treat. 2017;166(2):519–526. doi: 10.1007/s10549-017-4437-8
- Bao T, Basal C, Seluzicki C, et al. Long-term chemotherapy-induced peripheral neuropathy among breast cancer survivors: prevalence, risk factors, and fall risk. Breast Cancer Res Treat. 2016;159(2):327–333. doi: 10.1007/s10549-016-3939-0
- Kolb NA, Smith AG, Singleton JR, et al. The association of chemotherapy-induced peripheral neuropathy symptoms and the risk of falling. JAMA Neurol. 2016;73(7):860–866. doi: 10.1001/jamaneurol.2016.0383
- Ewertz M, Qvortrup C, Eckhoff L. Chemotherapy-induced peripheral neuropathy in patients treated with taxanes and platinum derivatives. Acta Oncol. 2015;54(5):587–591. doi: 10.3109/0284186X.2014.995775
- Molassiotis A, Cheng HL, Leung KT, et al. Risk factors for chemotherapy-induced peripheral neuropathy in patients receiving taxane- and platinum-based chemotherapy. Brain Behav. 2019;9(6):e01312. doi: 10.1002/brb3.1312
- Koyanagi M, Imai S, Nakagawa T, et al. [Identification of biomarkers and new therapies for taxane-induced peripheral neuropathy]. Nihon Yakurigaku Zasshi. 2019;154(5):241–244. (Japanese). doi: 10.1254/fpj.154.241
- Andersen Hammond E, Pitz M, Shay B. Neuropathic pain in taxane-induced peripheral neuropathy: evidence for exercise in treatment. Neurorehabil Neural Repair. 2019;33(10):792–799. doi: 10.1177/1545968319860486
- Rivera DR, Ganz PA, Weyrich MS, et al. Chemotherapy-associated peripheral neuropathy in patients with early-stage breast cancer: a systematic review. J Natl Cancer Inst. 2018;110(2):djx140. doi: 10.1093/jnci/djx140
- Salehifar E, Janbabaei G, Alipour A, et al. Taxane-induced peripheral neuropathy and quality of life in breast cancer patients. J Oncol Pharm Pract. 2020;26(6):1421–1428. doi: 10.1177/1078155219898511
- Song SJ, Min J, Suh SY, et al. Incidence of taxane-induced peripheral neuropathy receiving treatment and prescription patterns in patients with breast cancer. Support Care Cancer. 2017;25(7):2241–2248. doi: 10.1007/s00520-017-3631-x
- Atkins SLP, Zimmer AS. Neurologic complications of breast cancer. Cancer. 2023;129(4):505–520. doi: 10.1002/cncr.34518
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