Chemotherapy-induced peripheral polyneuropathy in breast cancer patients

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Abstract

Breast cancer is the second most common cancer overall, the most common cancer in women, and a leading cause of death in women. The incidence of brain metastases has increased due to longer patient survival. Thus, chemotherapy for breast cancer has significantly increased promising a positive outcome. However, long-term and repeated chemotherapy leads to involvement of the peripheral nervous system by creating clinical issues dominated by peripheral neuropathy and cognitive changes.

This literature review assesses the negative neurological effects of chemotherapy in breast cancer patients.

The review discusses neuropathic pain mechanisms, primarily neuroimmune and inflammatory changes, ion-channel remodeling, mitochondrial dysfunction, and genetic predisposition. The review gives advice on the prevention of peripheral neuropathy and neuropathic pain in breast cancer patients. It shows the relationship of chemotherapy and deteriorated quality of life, where special attention should be paid to early detection and treatment of chemotherapy-induced peripheral polyneuropathy to improve the quality of life of breast cancer patients.

With advances in pharmacology, the introduction of targeted therapy and its combinations, especially those involving epidermal growth factor receptor 2, the survival potential of breast cancer patients increases, but there are risks of more frequent neurological complications, primarily peripheral neuropathy and cognitive changes.

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About the authors

Sergey M. Karpov

Stavropol State Medical University

Email: karpov25@rambler.ru
ORCID iD: 0000-0003-1472-6024
SPIN-code: 3890-9809

MD, Dr. Sci. (Medicine), Professor, Head of the Department of Neurology, Neurosurgery and Medical Genetics

Russian Federation, Stavropol

Khava K.-S. Tambieva

Stavropol State Medical University

Email: khavatam@icloud.com
ORCID iD: 0000-0001-7884-2767

postgraduate student of the Department of Neurology, Neurosurgery and Medical Genetics

Russian Federation, Stavropol

Anna I. Klimenko

Stavropol State Medical University

Email: anyutikkovalenko@mail.ru
ORCID iD: 0000-0002-2201-7626
SPIN-code: 1736-0048

neurologist

Russian Federation, Stavropol

Irina A. Vyshlova

Stavropol State Medical University

Author for correspondence.
Email: irisha2801@yandex.ru
ORCID iD: 0000-0001-9187-8481
SPIN-code: 6908-7872

MD, Dr. Sci. (Medicine), Associate Professor of the Department of Neurology, Neurosurgery and Medical Genetics

Russian Federation, Stavropol

Arsen A. Koychuev

Stavropol State Medical University

Email: onco_stgmu@mail.ru
ORCID iD: 0000-0003-2856-1056
SPIN-code: 2196-6568

MD, Dr. Sci. (Medicine), Professor, Head of the Department of Oncology and Radiation Therapy

Russian Federation, Stavropol

Alexander V. Minin

Stavropol State Medical University

Email: aleksanderminin2016@yandex.ru
ORCID iD: 0009-0001-5054-1601

oncologist surgeon

Russian Federation, Stavropol

References

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