Vol XXXIV, No 3-4 (2002)

Original article

Mitochondrial disfunction in Friedreich disease: biochemical and cytochemical aspects

Ershova M.V., Illarioshkin S.N., Sukhorukov V.S., Klushnikov S.A., Phedorova T.N., Ivanova-Smolenskaya I.A.


Some lesions were revealed in the system of oxidation mitochondrial phosphorylation in Fredreich disease, as well as their correlation with the disease course at its different clinical variants. A vivid tendency has been traced to normalization of these cytochemical indices after single treatment by medicines, stabilizing mitochondrial functions.

Neurology Bulletin. 2002;XXXIV(3-4):5-11
pages 5-11 views

To the question of multiple sclerosis epidemiology on the territory of the Republic of Tatarstan

Kondratjeva O.S., Ismagilov M.F., Matveeva T.V., Saitgaleev I.Z.


The results had been given (spread, incidence and invalidization) of comparative analysis of multiple sclerosis for the last three years (1999—2001) in the Republic of Tatarstan. High indices of spread and incidence (more than 30 per 100 000 people) were revealed in those regions, which soils represent themselves geochemical anomalies (with the increased content of arsenic, mercury and decreased content of zync).

Neurology Bulletin. 2002;XXXIV(3-4):12-15
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Some factors, enfluencing multiple sclerosis (MS)

Matveeva T.V., Ismagilov M.F., Ishmanova S.A.


Some factors, enfluencing multiple sclerosis development, have been studied. Connection of tire disease with living close to metallurgical plants has been confirmed, as well as with prevailing meat products in food and with craniocerebral trauma. For the first time association of multiple sclerosis with infectionous eye diseases has been revealed, as well us with soft tissue absesses, critical dental caries, with contact with birds and with age of a father (senior than 31 y.o.) at the moment of a patient birth. The factors, determining unfavourable course of MS are: craniocerebral trauma without loss of consciousness, contact with agricultural animals, prevailing meat products in nutrition of persons at the age of untill 15 y.o. and disease beginning with cerebellar symptomatology.

Neurology Bulletin. 2002;XXXIV(3-4):16-20
pages 16-20 views

Character of ТТН in children and adolescents

Yudelson Y.B., Ratchin A.P.


The article reflects the present-day concepts of tension-type headache (ТТН) whose incidence among children is known to amount 28,7%-72,8%. Is represents the variants of classification of this condition, describing etiology and probably pathogenesis of TTH. Of special interest to various specialty physicians seems to part of the article dealing with the problems of diagnosis of this disease. The authors have summarized their own experience and the finding of Russian and foreign research carried out over in recent years to study varies aspects of tension-type headache in children.

Neurology Bulletin. 2002;XXXIV(3-4):24-30
pages 24-30 views

HLA complex antigens at infantile cerebral paralysis in Kazan population

Gainetdinova D.D., Ismagilov M.F., Pakhalina I.A.


A complex clinico-instrumental and immunogenetic study has been performed in 34 patients with different forms of infantile cerebral palsy in Kazan population. HLA-typing has revealed a reliable disease association with antigen B13. The control group was made up of 115 healthy patients. For the first time a comparable risk criteria has been counted: if a patient has B13 antigen — risk of infantile cerebral paralysis development increases by 3.55 times. Contribution of HLA-B13 associated gene into genesis of the disease makes up not less than 11,6%. The study results testify to heridatary mechanisms envolvement into etiopathogenesis of infantile cerebral paralysis and demand further study of genetic peculiarities of «susceptibility» genome to different harmful factors.

Neurology Bulletin. 2002;XXXIV(3-4):21-23
pages 21-23 views

Investigation of the pathogenesis of vertigo and new mechanism of therapeutical effect of Betaserc

Afanassieva S.A., Gorbacheva F.E., Natiashkina G.M.


In a 4-year period survey, etiopathogenetic mechanism of vertigo was studied in 43 prospective controls and 75 patients hospitalized with acute onset of vertigo. Impaired venous circulation of transverse sinuses has been found with intact arterial part of cerebral circulation. New information is available that shows the complementary mechanism of vertigolytic effect of Betaserc which improves intracranial venous circulation.

Neurology Bulletin. 2002;XXXIV(3-4):31-34
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Correlation of electrophysilogic indices of electroencephalograms (EEG) and caused potentials in convalescents after hemorrhagic fever with renal syndrome (HFRS)

Novikova L.B., Burashnikova Y.A., Suvorov A.G.


Changes of caused potentials at hemorrhagic fever with renal syndrome have been studied, as well as correlation of these indices to EEG data. Mathematical and statistical analysis of EEG parameters and caused potentials in convalescents after HFRS showed significant deviations in brain bioelectric activity; these deviations being characterized by a considerable decrease of amplitude characteristics of the EEG basic rhythms with a tendency to rhythm frequency lowering practically in all cerebral cortex regions, prolongation of latent periods and decrease of caused potentials amplitude. Changes in visual caused potentials can indicate to the cerebral demyelinization process. This correlation analysis has revealed an interchange between different electrophysiologic characteristics.

Neurology Bulletin. 2002;XXXIV(3-4):35-38
pages 35-38 views


Modern concepts of molecular genetic mechanisms and pathogenesis of the main forms of idiopathic generalized epilepsy

Perunova N.Y.


In the International Classification of Epilepsies and Epileptic Syndromes in 1989 [7], syndromes of both partial and generalized and symptomatic, cryptogenic and idiopathic epilepsy are distinguished. The latter are characterized as “diseases not caused by obvious causes, with the exception of the alleged hereditary predisposition and occur in 25-30% of all epilepsy cases [2]. Idiopathic generalized epilepsies (IGE) are characterized by such common features as the onset of seizures mainly in childhood and adolescence, a high incidence of epilepsy among relatives, the absence of any organic brain disease that causes epilepsy, and focal symptoms in the neurological status, and normal intelligence of patients. , absence of gross morphological changes in the brain during neuroimaging. The IGE is also characterized by the presence of a triad of primary generalized seizures (absences, myoclonic paroxysms and generalized seizures) in any combination, registration on the EEG in the interictal period of spike-wave and polyspike-wave epileptiform activity and the possibility of arresting all seizures (especially valproate) [ 2].

Neurology Bulletin. 2002;XXXIV(3-4):39-44
pages 39-44 views

Symptomatic therapy for spasticity

Тахавиева F.V., Bogdanov E.I.


Spasticity is a violation of muscle tone that occurs with central paralysis, is characterized by an increase in tonic stretch reflexes, is associated with an increase in tendon reflexes and other signs of damage to the central motor neuron [19, 22]. A large number of works are devoted to the mechanisms of its formation and clinical phenomenology in various diseases accompanied by damage to the central motor neurons [11, 19, 21, 22, 25]. It is known that spasticity is not the result of a violation of any one system - the spinal or cerebral, or one neurophysiological mechanism, but is caused by presynaptic disinhibition of GABAergic 1A terminals, a decrease in glycerinergic reciprocal inhibition, hyperexcitable depressive alpha motoneurons, 1 glycerinergic inhibition [14, 25]. Since spasticity cannot be explained by any one type of pathophysiological disorder and includes changes in both pre- and postsynaptic inhibition, it is difficult to develop an effective treatment for it. However, there are certain drugs, surgical manipulations, methods of restorative treatment, which, to one degree or another, reduce the manifestations of spasticity. Before starting such treatment, it is necessary to analyze all the facts in the clinical picture of a particular patient. First, it is necessary to decide whether the spasticity is sufficiently pronounced and whether this justifies the conduct of special therapy. Secondly, one should differentiate between true spasticity and changes in the mechanical properties of muscles. Finally, it is known that the severity of spasticity can be aggravated by various factors, both external (eg cold) and internal (eg, bladder infection or excitement) [14].

Neurology Bulletin. 2002;XXXIV(3-4):45-50
pages 45-50 views


The meaning of life and healing

Troshin V.D.


The problem of the meaning of life is connected with the general problem of the Universe, its place in the general development of the Universe, the evolution of man and mankind, the specific meaning of life of each person - with the satisfaction of his basic needs, in particular biological, social and spiritual. The meaning of every person's life is determined by the desire for continuous self-improvement, while if the person himself improves, then the whole of humanity is also improved.

Neurology Bulletin. 2002;XXXIV(3-4):51-58
pages 51-58 views

Experience exchange

Bartel's index in assessing the recovery of patients with cerebral stroke in the acute period of the disease

Bogdanov E.I., Тахавиева F.V.


The problem of rehabilitation treatment of patients who have suffered a cerebral stroke is extremely relevant due to its widespread prevalence, high rates of mortality and disability. One of the main reasons for persistent disability are, along with impaired speech function, psychological and social maladjustment, impaired motor functions of patients.

Neurology Bulletin. 2002;XXXIV(3-4):59-60
pages 59-60 views

Results of a clinical study of the drug bilobil

Sokolova T.V., Dubova M.N., Pavlov S.S.


For clinical study, bilobil was presented in the form of dark lilac capsules containing a yellowish powder with a specific odor, bitter in taste, which is an extract of the leaves of the relict tree ginkto biloba, at a dose of 40 mg.
The active components of the extract are flavonoids, ginkcolides and bilobalides, which dilate blood vessels, improve blood circulation, metabolism, prevent platelet aggregation, and protect cells and tissues from damage resulting from a lack of oxygen. Bilobil capsules improve blood supply to the brain, metabolism and prevent decreased performance. Acting on neuronal transmission by facilitating the release of monoamines into the synaptic cleft and increasing the density of synaptic receptors, the drug has a beneficial effect on brain structures.

Neurology Bulletin. 2002;XXXIV(3-4):61-63
pages 61-63 views

Successful surgical treatment of a patient with traumatic kyphoscoliosis and secondary lower paraplegia

Ibragimov Y.K.


Severe kyphoscoliosis and their complications are one of the causes of disability and mortality in people of working age. After individual correction of gross deformities of the spine, followed by stabilization, regression of severe neurological complications often occurs.

Neurology Bulletin. 2002;XXXIV(3-4):64-65
pages 64-65 views

Psychophysiological research and tasks of neuroprophylaxis

Andrushchakevich A.A., Troshin V.D.


In the recent past, a new direction in medicine began to take shape - preventive neurology, the purpose of which is the prevention of major diseases of the nervous system and the strengthening of the neuropsychic health of the population. The main tasks of preventive neurology were also formulated: development of publicly available research methods for mass examinations and clinical examination of the population; study of the characteristics of the nervous system of healthy individuals, risk factors for major diseases of the nervous system and their early diagnosis; creation of integrated systems for mass and individual prevention of nervous diseases (VD Troshin, LP Shubina, 1988).

Neurology Bulletin. 2002;XXXIV(3-4):66-67
pages 66-67 views


Review of the monograph by E.G. Mendelevich, M.K. Mikhailova, E.I. Bogdanov "Syringomyelia and Arnold-Chiari malformation" (clinical and neurovisual aspects)

Ivanichev G.A.


The emergence of the possibility of MRI tomographic diagnostics of neurological diseases stimulated the opening of a new era in the study of syringomyelia. The detection of a frequent combination of Arnold-Chiari malformation with syringomyelia made it possible to revise in many ways the traditional ideas about the nature of this disease.

Neurology Bulletin. 2002;XXXIV(3-4):68-68
pages 68-68 views


Hot water epilepsy (J. Child. Neurol. — 2000. Feb. —15(2). — p. 125—128: англ.)

Ioos C., Fohlen M., Villeneuve N., Badinand-Hubert N., Jalin C., Cheliout-Heraut F., Pinard J.


This study describes 5 cases of epileptic seizures when bathing in a hot bath in children aged 6 months to 2 years. The children were somatically healthy and developing normally. In all cases, the course of epilepsy was mild. The regression of symptoms occurred either after the prescription of antiepileptic drugs, or when the bathing regimen was changed.

Neurology Bulletin. 2002;XXXIV(3-4):69-69
pages 69-69 views

Synchronous neuronal activity is a signal for axonal sprouting after cortical lesions in the adult (J. of Neuroscience. — 2002. Jul. — 15, 22 (14). —P. 6062—6070: англ.)

Carmichael S., Chesselet M.


It was found that immediately after ischemic damage, neurons begin to produce electrical impulses of a special frequency, which cause activation of regenerative processes. According to the authors of the work, these neuronal impulses are similar to those that take place in the brain during maturation.

Neurology Bulletin. 2002;XXXIV(3-4):69-69
pages 69-69 views

The usefulness of children’s drawings in the diagnosis of headache (Pediatrics. — 2002. Mar. — 109 (3). — P. 460-472: англ.)

Stafstrom C., Rostasy K., Minster A.


The aim of the work was to determine the information content of the figures in the differential diagnosis of migraine and non-migraine headache in children. The need for such a study is dictated by the fact that young children usually cannot accurately characterize headaches, and this makes it difficult to correctly diagnose.

Neurology Bulletin. 2002;XXXIV(3-4):69-70
pages 69-70 views

Generation of dopaminergic neurons and pigmented epithelia from primate es cells by stromal cell-derived inducing activity (Proc. Natl. Acad. Sci. — 2002. Feb. — 99 (1). — P. 1580—1585: англ.)

Kawasaki H., Suemori H., Mizuseki K.


Embryonic cell transplantation is a promising treatment for Parkinson's disease. However, the application of this method is limited due to the difficulties in obtaining a sufficient amount of material for implantation. A solution to this problem can be expected from the results of the work of a group of Japanese researchers.

Neurology Bulletin. 2002;XXXIV(3-4):70-70
pages 70-70 views

Cytotoxin-associated gene-A-positive Helicobacter pylori strains are associated with atherosclerotic stroke (Circulation. — 2002. Jul. — 30. — 106 (5). —P. 580—584: англ.)

Diomedi M., Silvestrini M.


Italian researchers from the University of Tor Vergata have found that some species of Helicobacter pylori bacteria with cytotoxin-associated gene-A (CagA) are significantly more likely to be found in patients who have suffered from stroke associated with atherosclerotic vascular lesions.

Neurology Bulletin. 2002;XXXIV(3-4):70-70
pages 70-70 views

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