The frequency of somatic mutations in EGFR gene in smoking and non-smoking patients with lung adenocarcinoma


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Abstract

Lung cancer is one of the most common malignancies in the world. On the territory of the Russian Federation, in particular the Novosibirsk region, there is an increase in the number of morbidity and mortality from lung cancer. There are many factors leading to the development of this disease, such as smoking, environment, etc. One of the possible options for the development of lung cancer are activating mutations in the gene for the receptor of epidermal growth factor (EGFR). Activation of EGFR plays a crucial role in tumor proliferation, survival and metastasis, so EGFR is a target for targeted therapy. The frequency of activating mutations in the EGFR gene depends on many factors, including regional features. For example, the frequency of such mutations is particularly high in nonSmoking women in East Asia. The purpose of this study is the analysis of the prevalence of non-small cell lung cancer, particularly adenocarcinoma of the lung in the Novosibirsk region, and the frequency of its occurrence depending on the Smoking and the presence of mutations in EGFR in men (n=352) women (n=197). The results of the study showed that lung adenocarcinoma occurs in male smokers in 52.3%, and non-smokers in 43.5%. At the same time, mutation in EGFR in non-Smoking men (6%) was higher than in smokers (2.6%). In the study of the female group, the incidence of lung adenocarcinoma in Smoking women was 6.2%, and in non -smokers- 92.6%. Mutation in EGFR was detected in 35.5% of non-smoking patients, while smoking women with lung adenocarcinoma, mutation in EGFR was not detected. Thus, the results indicate different pathogenetic mechanisms of lung cancer development in men and women, depending on Smoking and the presence of mutations in the EGFR gene. A feature is a fairly high frequency of mutations of EGFR (up to 35.5%) in non-Smoking women with lung adenocarcinoma in the Novosibirsk region.

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About the authors

E. A Badaev

State Regional Novosibirsk Clinical Tuberculosis Hospital; Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences

Email: Eugene3007@gmail.com
Surgeon; Post-graduate Student

V. V Fazlov

Novosibirsk Regional Clinical Oncologic

Email: vadimkozlov80@mail.ru
Ph.D. (Med.), Head of Department

T. A Kvon

Novosibirsk State University

Email: tatyanakwon@yandex.ru
Student, V. Zelman Institute for the Medicine and Psychology

L. F Gulyaeva

Fedaral Research Center of Fundamental and Translational Medicine; Novosibirsk State University

Email: lfgulyaeva@gmail.com
Dr.Sc. (Biol.), Professor, Head of Laboratory; Heads of Department^ V. Zelman Institute for the Medicine and Psychology

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