Analysis of the mechanism of action of the Galega officinalis L

Galega medicinal (Galega officinalis L.) is a perspective medicinal plant of antidiabetic action. Positive influence of a galega on various links of pathological process at a diabetes mellitus is explained by the maintenance of a complex of biologically active agents, one of which is guanidinovy alkaloid galegine (izoamilen-guadin). Galegine can work like guanyl guanidines - group of synthetic glucose-lowering drugs, for example as Metforminum, the patients with a diabetes mellitus who are applied to treatment. The similarity of pharmacological activity of galegine and metformin is caused by proximity of chemical composition and respectively proximity of mechanisms of effect of the specified substances. According to literary data an important target of Metforminum is adenosinemono-phosphate - the activated protein kinase (AMFK) - the key regulator of power metabolism of a cell. Activation of AMFK leads to reduction of endothelial dysfunction, easing of an oxidative stress, improvement of utilization of glucose and increase in biological activity of insulin. Such metabolic activity does this enzyme by one of major factors of protection of a cardiovascular system in the conditions of a diabetes mellitus and can explain various effects of guanyl guanidines. Also the LKB1/AMFK mechanism provides molecular interrelation between a diabetes mellitus and cancer. Metforminum reduces metabolic defect and restored generation of T-memory cells. The mechanism of effect of metformin and a galega medicinal opens a wide range of their pharmacological action.

galegalekarstvenny, alkaloid galegine, metformin, diabetes mellitus, antidiabetic means, guanyl guanidine