TECHNOLOGICAL ASPECTS OF OBTAINING MICROCAPSULES OF PLANT ORIGIN SUBSTANCES


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Abstract

The review presents data devoted to the specifics of microencapsulation of plant origin drugs, technological aspects of various microencapsulation methods and possibilities of microencapsulation application for solving problems related to the storage and stability of active substances. Domestic and foreign sources of open access literature were analyzed; the following electronic databases were used: PubMed, Elibrary, CyberLeninka and Google Scholar search system. The article presents features of microencapsulation methods and conditions of their application in practice. The limitations of the tech-nigues related to the physico-chemical properties of biologically active substances, namely the aggregate condition, solubility, low decomposition temperatures of active substances, changes in properties when interacting with other components, etc., have been identified. The conditions for efficient microencapsulation process, allowing to obtain particles with the given properties, have been investigated. The main encapsulation methods currently used for obtaining microcapsules are described. The conditions of application of methods for obtaining microcapsules of biologically active substances of plant origin are considered. The medicinal substances derived from plants, depending on the constituent components, reguire certain restrictions, namely the selection of temperature regime, excipients and eguipment, in the use of which the gualitative and guantitative composition of the substance remains unchanged.

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About the authors

O. A Semkina

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Email: semkinaolga@gmail.com
Ph.D. (Pharm.) Moscow, Russia

M. A Dzhavakhyan

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Dr.Sc. (Pharm.), Associate Professor, Chief Research Scientist Moscow, Russia

O. M Beloshapkina

M.V. Lomonosov Moscow State University

Student, Faculty of Fundamental Medicine Moscow, Russia

A. N Gromakova

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Dr.Sc. (Pharm.), Chief Research Scientist Moscow, Russia

References

  1. Lengyel M., Kallai-Szabo N., Antal V. etal. Microparticles, microspheres, and microcapsules for advanced drug delivery. Sci Pharm. 2019; 87(20): 1-31.
  2. Kalusevic A., Veljovic M., Salevic A. et al. Microencapsulation of herbs extract by spray drying. Work Fac Agric Food Sci. 2016; 61(66): 151-155.
  3. Carvalho I.T., Estevinho B.N., Santos L. Application of microencapsulated essential oils in cosmetic and personal healthcare products - a review. Int J Cosmet Sci. 2016; 38(2): 109-19.
  4. Вилесова М.С., Айзенштадт Н.И., Босенко М.С. и др. Разработка микрокапсулированных и гелеобразных продуктов и материалов для различных отраслей промышленности. Российский химический журнал. 2001; 45: 1-10.
  5. Farheen T., Shaikh A., Shahi S. AReview on a Process: Microencapsulation. Int J Pharma Res Heal Sci. 2017; 5(5): 1823-1830.
  6. Редченкова В.Н., Хишова О.М. Анализ требований некоторых фармакопей, предъявляемых к экстрактам. Химико-фармацевтический журнал. 2006; 40(1): 37-40.
  7. Охотникова В. Ф., Качалина Т.В., Балакина М.В. и др. Современное состояние и перспективы развития технологии твердых лекарственных форм для внутреннего применения с растительными сухими экстрактами. Вопросы биологической, медицинской и фармацевтической химии. 2012; 1: 139-143.
  8. Neubauer M.P., Poehlmann M., Fery A. Microcapsule mechanics: From stability to function. Adv Colloid Interface Sci. 2014; 207: 65-80.
  9. Garg A., Chhipa K., Kumar L. Microencapsulation Techniques in Pharmaceutical Formulation. Eur J Pharm Med Res. 2018; 5(3): 199-206.
  10. Righi da Rosa J., Nunes G.L., Motta M.H. et al. Microencapsulation of anthocyanin compounds extracted from blueberry (Vaccinium spp.) by spray drying: Characterization, stability and simulated gastrointestinal conditions. Food Hydrocoll. 2019; 89: 742-748.
  11. Полковникова Ю.А., Степанова Э.Ф., Куль И.Я. Биофармацевтические исследования афобазола. Актуальные проблемы мед. 2010; 10(81): 1-4.
  12. Автина Н.В., Писарев Д.И., Новиков О.О. и др. Разработка состава и технологии микрокапсул с экстрактом черемухи поздней. Современные проблемы науки и образования. 2012; 4: 1-8.
  13. Меньшутина Н.В. Технологии инкапсуляции. Фармацевтические технологии и упаковка. 2014; 3: 44-47.
  14. Patil S. Encapsulation of Orange oil using fluidized bed granulation. 2019. 66.
  15. Shakoori P., Krasaekoopt W. Microencapsulation of Saffron [Crocus sativus L.] extract in copolymer complexes using extrusion method. Chiang Mai Univ J Nat Sci. 2015; 14(1): 57-76.
  16. Tavares L., Barros H.L.B., Vaghetti J.C.P. et al. Microencapsulation of Garlic Extract by Complex Coacervation Using Whey Protein Isolate/Chitosan and Gum Arabic/Chitosan as Wall Materials: Influence of Anionic Biopolymers on the Physicochemical and Structural Properties of Microparticles. Food Bioprocess Technol. 2019; 12(12): 2093-2106.
  17. Brito de Souza V., Thomazini M., Chaves I.E. et al. Microencapsulation by complex coacervation as a tool to protect bioactive compounds and to reduce astringency and strong flavor of vegetable extracts. Food Hydrocoll. 2020; 98: 1-40.
  18. Muhaimin M., Yusnaidar Y., Syahri W. et al. Microencapsulation of macaranga gigantea leaf extracts: Production and characterization. Pharmacogn J. 2020; 12(4): 716-724.
  19. Кролевец А.А., Богачев И.А., Никитин К.С. и др. Способ получения микрокапсул сухого экстракта топинамбура в пектине. Российская Федерация: Федеральная служба по интеллектуальной собственности; RU 2555824 C1-2014. 1-9.
  20. Elkharraz K., Ahmed A.R., Dashevsky A. et al. Encapsulation of water-soluble drugs by an o/o/o-solvent extraction microencapsulation method. Int J Pharm. 2011; 409(1-2): 89-95.
  21. Мусабаева Б.Х., Мурзагулова К.Б., Ким М.Е. и др. Получение микрокапсул противотуберкулезных препаратов на основе биополимеров и полиэлектролитов. Фармация и фармакология. 2017; 5(2): 164-176.
  22. Piccinino D., Capecchi E., Botta L. et al. Layer-by-Layer Preparation of Microcapsules and Nanocapsules of Mixed Polyphenols with High Antioxidant and UV-Shielding Properties. Biomacromolecules. 2018; 19(9): 3883-3893.
  23. Wissam Z., Samer H. Encapsulation of flaxseed oil extract in alginate-salep system by ionic gelation. Brazilian J Pharm Sci. 2019; 55(12): 1-9.

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