TECHNOLOGICAL ASPECTS OF OBTAINING MICROCAPSULES OF PLANT ORIGIN SUBSTANCES


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The review presents data devoted to the specifics of microencapsulation of plant origin drugs, technological aspects of various microencapsulation methods and possibilities of microencapsulation application for solving problems related to the storage and stability of active substances. Domestic and foreign sources of open access literature were analyzed; the following electronic databases were used: PubMed, Elibrary, CyberLeninka and Google Scholar search system. The article presents features of microencapsulation methods and conditions of their application in practice. The limitations of the tech-nigues related to the physico-chemical properties of biologically active substances, namely the aggregate condition, solubility, low decomposition temperatures of active substances, changes in properties when interacting with other components, etc., have been identified. The conditions for efficient microencapsulation process, allowing to obtain particles with the given properties, have been investigated. The main encapsulation methods currently used for obtaining microcapsules are described. The conditions of application of methods for obtaining microcapsules of biologically active substances of plant origin are considered. The medicinal substances derived from plants, depending on the constituent components, reguire certain restrictions, namely the selection of temperature regime, excipients and eguipment, in the use of which the gualitative and guantitative composition of the substance remains unchanged.

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作者简介

O. Semkina

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Email: semkinaolga@gmail.com
Ph.D. (Pharm.) Moscow, Russia

M. Dzhavakhyan

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Dr.Sc. (Pharm.), Associate Professor, Chief Research Scientist Moscow, Russia

O. Beloshapkina

M.V. Lomonosov Moscow State University

Student, Faculty of Fundamental Medicine Moscow, Russia

A. Gromakova

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Dr.Sc. (Pharm.), Chief Research Scientist Moscow, Russia

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