Evaluation of the efficiency of use of a biologically active supplement based on the extract of galega officinalis in the complex therapy of type 2 diabetes mellitus


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Abstract

Relevance. Diabetes mellitus is one of the most common chronic diseases in the world. The vast majority of patients suffering from this pathology have type 2 diabetes mellitus, for the treatment of which drugs with various effects on metabolic processes are used. In recent years, the interest in a study of medicinal plants with antidiabetic activity has grown in the scientific and medical community. The purpose of this work was to study the efficiency and safety of the complex application of a biologically active supplement (dietary supplement) to food based on the extract of the herb Galega officinalis L. in disorders of carbohydrate metabolism in patients with type 2 diabetes mellitus. Results. When using dietary supplements in combination with basic therapy in patients with type 2 diabetes mellitus, there was a significant improvement in glycemic variability indices by the end of the study. Intraday fluctuations in glucose levels significantly decreased, the frequency of hyperglycemic phenomena decreased, glycemic indices were within the target range. The main indicator of diabetes mellitus compensation is the determination of the level of glycated hemoglobin HbA1c. In the group of patients with dietary supplements compared with basic therapy, there was a significant decrease in the level of glycated hemoglobin: HbA1c in the group of patients with dietary supplements decreased by 0.8%, and in the group of standard therapy increased by 0.05%. This indicates a positive dynamics of the glycemic profile and a decrease in the rate of development of late complications of diabetes mellitus. Conclusion. Thus, the continuous monitoring of glycemia testified to the efficiency and safety of the use of dietary supplements based on the extract of the herb Galega officinalis in the complex therapy of type 2 diabetes mellitus.

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About the authors

V. N Burkova

"Biolit" LLC

Email: infobiolit@yandex.ru

Dr.Sc. (Chem.), Director of Science and Innovation

V. P Sergun

"Biolit" LLC

Email: infobiolit@yandex.ru

Ph.D. (Chem.), Director

A. A Ivanov

"Biolit" LLC

Email: infobiolit@yandex.ru
Ph.D. (Chem.), Head of Research Department

Yu. G Samoylova

Siberian State Medical University

Email: infobiolit@yandex.ru

Dr.Sc. (Med.), Professor, Department of Endocrinology and Diabetology

O. A Oleinik

Siberian State Medical University

Author for correspondence.
Email: infobiolit@yandex.ru

Ph.D. (Med.), Associate Professor, Department of Faculty Therapy with a Course of Clinical Pharmacology

References

  1. International Diabetes Federation. IDF Diabetes Atlas. 10th ed. Brussels: IDF. 2021. [Электронный ресурс]. URL: https://diabetesatlas.org.
  2. Шарофова М.У., Сагдиева Ш.С., Юсуфи С.Д. Сахарный диабет: современное состояние вопроса (ч. 1). Вестник Авиценны. 2019; 21(4): 661-674.
  3. Дедов И.И., Шестакова М.В., Майоров А.Ю. и др. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. Выпуск 8. Сахарный диабет. 2017; 20(1 S): 1-121.
  4. Diabetes mellitus. Report of WHO study group. World Health Organ. Techn. Rep. Ser. 2005; 727: 1-113.
  5. Jamila F., Mostafa E. Ethnobotanical survey of medicinal plants used by people in Oriental Morocco to manage various ailments. J. Ethnopharmacol. 2014; 154(1): 76-87.
  6. Barchuk O.Z., Lysiuk, R.M. et al. Experimental study of goat’s rue (Galega officinalis L.) herb and its liquid extracts. Pharma Innov. J. 2017; 6(11): 393-397.
  7. Мартынчик И.А., Трумпе Т.Е., Ферубко Е.В. Анализ механизма действия галеги лекарственной (Galega officinalis L.). Вопросы биологической, медицинской и фармацевтической химии. 2019; 9: 12-15.
  8. Якимова Т.В., Буркова В.Н., Ухова Т.М. Влияние галеги лекарственной на течение экспериментального сахарного диабета. Бюллютень сибирской медицины. 2006; 5(2): 146-147.
  9. Якимова Т.В., Насанова О.Н., Венгеровский А.И. и др. Влияние экстракта галеги лекарственной на метаболизм липидов при экспериментальном сахарном диабете. Сибирский медицинский журнал. 2011; 26(4): 98-102.
  10. ГОСТ Р-52379-2005 «Надлежащая клиническая практика». М.: Стандартинформ. 2006; 38 с.
  11. Калькулятор вариабельности гликемии EasyGV версия 9.0R2. [Электронный ресурс]. URL: https://www.phc.ox.ac.uk/research/technology-outputs/easygv.
  12. Pickup J.C., Freeman S.C., Sutton A.J. Glycaemic control in type 1 diabetes during real time continuous glucose monitoring compared with self-monitoring of blood glucose: metaanalysis of randomised controlled trials using individual patient data. BMJ. 2011; 343: d3805.
  13. Аметов А.С. Уровень гликированного гемоглобина как значимый маркер полноценного гликемического контроля и предиктор поздних сосудистых осложнений сахарного диабета 2-го типа. РМЖ. 2011; 13: 832-387.
  14. Пашинцева Л.П., Буданцева Т.А., Анциферов М.Б. и др. Международные требования к исследованиям гликированного гемоглобина. Справочник заведующего КДЛ. 2011; 3: 16-21.

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