Antiradical activity of 2,5-diaryl-8,8-dimethyl- 3,6,7,8-tetrahydro-2H-pyrido [4,3,2-de]cinnolin-3-ones
- Authors: Zykova S.S.1, Namyatova K.V.1, Lystsova E.A.2, Shurov S.N.2
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Affiliations:
- Federal State Budgetary Educational Institution of Higher Education "Perm State Pharmaceutical Academy"
- Federal State Autonomous Educational Institution of Higher Education «Perm State National Research University»
- Issue: Vol 26, No 2 (2023)
- Pages: 28-31
- Section: Pharmaceutical chemistry
- URL: https://journals.eco-vector.com/1560-9596/article/view/248114
- DOI: https://doi.org/10.29296/25877313-2023-02-04
- ID: 248114
Cite item
Abstract
Relevance. The development of most pathological processes is based on oxidative stress, which is the result of an imbalance between free radicals and antioxidants. The presence of an unpaired electron provides a high reactivity of free radicals and allows easy reaction with cell compartments, which leads to disruption of their work. Free radical oxidation of cellular structures underlies the pathogenesis of many diseases (oncological, cardiovascular, neurodegenerative, etc.), as well as the aging process. Thus, free radicals can be considered as a target for new antioxidants.
Target. Investigation of antiradical activity of synthesized 2,5-diaryl-8,8-dimethyl-3,6,7,8-tetrahydro-2H-pyrido [4,3,2-de]cinnolin-3-ones.
Material and methods. 2,5-Diaryl-8,8-dimethyl-3,6,7,8-tetrahydro-2H-pyrido [4,3,2-de]cinnolin-3-ones were obtained as a result of the interaction of 2-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-4-carboxylic acids with o-tolyl-, p-tolyl-, p-fluorine, p-nitro-, 2,4,6-trichloro-phenylhydrazines. As a result, 10 compounds were synthesized, the structure of which was confirmed by IR and 1H NMR spectroscopy. The antiradical activity of 10 compounds was studied using the method of binding a stable radical with 2,2-diphenylpicryl-1-hydrazyl (DPPH).
Conclusion. Compounds of a number of 2,5-diaryl-8,8-dimethyl- 3,6,7,8-tetrahydro-2H-pyrido[4,3,2-de]cinnoline-3-ones don’t have pronounced antiradical activity, which indicates the presence of another mechanism of antioxidant action.
Conclusions. Further investigation will reveal the mechanism of antioxidant action of 2,5-diaryl-8,8-dimethyl-3,6,7,8-tetrahydro-2H-pyrido[4,3,2-de]cinnoline-3-ones, therefore it is advisable.
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About the authors
S. S. Zykova
Federal State Budgetary Educational Institution of Higher Education "Perm State Pharmaceutical Academy"
Author for correspondence.
Email: zykova.sv@rambler.ru
Dr.Sc. (Biol.), Associate Professor, Head of the Department of Pharmacology
Russian Federation, PermK. V. Namyatova
Federal State Budgetary Educational Institution of Higher Education "Perm State Pharmaceutical Academy"
Email: yakristina_1999@mail.ru
Post-graduate Student
Russian Federation, PermE. A. Lystsova
Federal State Autonomous Educational Institution of Higher Education «Perm State National Research University»
Email: zykova.sv@rambler.ru
Post-graduate Student
Russian Federation, PermS. N. Shurov
Federal State Autonomous Educational Institution of Higher Education «Perm State National Research University»
Email: zykova.sv@rambler.ru
Dr.Sc. (Chem.), Professor, Department of Organic Chemistry
Russian Federation, PermReferences
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