Phyto-stimulating effects of paracetamol biodestruction product on urtica dioica
- Authors: Vikhareva E.V.1, Slabinskaya E.V.1, Mishenina I.I.1, Rubzov D.F.1, Rychkova M.I.2
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Affiliations:
- Perm State Pharmaceutical Academy
- Ural Branch of the Russian Academy of Sciences
- Issue: Vol 26, No 5 (2023)
- Pages: 32-37
- Section: Pharmaceutical chemistry
- URL: https://journals.eco-vector.com/1560-9596/article/view/456467
- DOI: https://doi.org/10.29296/25877313-2023-05-05
- ID: 456467
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Abstract
Relevance. The search for environmentally friendly methods of processing pharmaceutical waste to obtain new biologically active compounds on their basis, including phytostimulating action, is especially relevant in recent years due to global pharmaceutical pollution of water bodies in many countries. The results of previous studies have shown that the product of bacterial degradation of paracetamol exhibits pronounced phytostimulating properties in relation to medicinal plants of Plantaginaceae, Asteraceae, Linaceae, Lamiaceae and other families.
The purpose of this study is to study the effect of PBP on morphometric parameters, dry biomass and the content of biologically active substances in the leaves of stinging nettle (Urtica dioica L.), a medicinal plant of the family. nettles (Urticaceae).
Material and methods. We used bacterial degradation of paracetamol obtained on the basis of the Laboratory of Alkanotrophic Microorganisms, PFRC, Ural Branch, Russian Academy of Sciences (Perm). Stinging nettle leaves collected from plants treated with bacterial degradation of paracetamol were used to determine the biomass by gravimetric method, morphometric parameters, as well as the content of the total free organic acids, hydroxycinnamic acids and ascorbic acid by titrimetric analysis and spectrophotometry. Water and alcohol extracts from medicinal plant materials were obtained according to the method of the Global Fund XIV ed.
Results. Under the influence of bacterial degradation of paracetamol, the morphometric parameters – the length and width of the nettle leaves increase by 115 % and 66 %, respectively, the total collection of leaf biomass increases by 40 % compared to the control (water). The increase in the content of the total free organic acids under the influence of bacterial degradation of paracetamol is 18.5%, hydroxycinnamic acids – 6.8%, ascorbic acid – 12.5%.
Conclusion. The product of bacterial degradation of paracetamol has a obvious phytostimulating effect on stinging nettle.
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About the authors
E. V. Vikhareva
Perm State Pharmaceutical Academy
Author for correspondence.
Email: ajm@perm.ru
ORCID iD: 0000-0002-7202-0073
Dr.Sc. (Pharm.), Professor, Head of Department of Analytical Chemistry
Russian Federation, PermE. V. Slabinskaya
Perm State Pharmaceutical Academy
Email: slabliza@yandex.ru
ORCID iD: 0000-0001-8537-8800
Post-graduate Student, Department of Analytical Chemistry
Russian Federation, PermI. I. Mishenina
Perm State Pharmaceutical Academy
Email: irin-mishenin@yandex.ru
ORCID iD: 0000-0002-6496-7427
Ph.D. (Pharm.), Associate Professor, Department of Pharmaceutical Technology
Russian Federation, PermD. F. Rubzov
Perm State Pharmaceutical Academy
Email: dennipermcity@gmail.com
ORCID iD: 0000-0002-1109-7675
Student
Russian Federation, PermM. I. Rychkova
Ural Branch of the Russian Academy of Sciences
Email: richkova@iegm.ru
ORCID iD: 0000-0002-6598-5870
Ph.D. (Biol.), Research Scientist
Russian Federation, PermReferences
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