Human antimicrobial peptides (review)

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Abstract

Relevance. The relevance of the antimicrobial peptides study is justified by the serious problem of antibiotic resistance, which presents a worrisome prospect of a significant number of deaths and economic losses in the future. In recent years, scientists have increasingly focused on natural substances, such as antimicrobial peptides, which do not induce bacterial resistance and may be safer for the human body compared to antibiotics.

Aim of the research. This review article aims to structure the scientific literature on exploring the potential applications and generation of peptide complexes from the human body.

Material and methods. The following databases were used for information retrieval: PubMed, American Society for Microbiology, ResearchGate, Frontiers Research Foundation, Public Library of Science, BioRxiv, Nature Communications, European Commission.

Results. The paper provides a description, structure, history of discovery, and research on antimicrobial peptides derived from the human body. The biological properties of these peptides are outlined. The prospects for further studying their properties and developing new-generation antibacterial drugs from them are presented.

Conclusions. The investigation of human antimicrobial peptides and the development of innovative drugs based on them represent a promising direction in modern biotechnology. The systematic analysis of scientific data regarding the possibility of obtaining and utilizing peptide complexes from the human body signifies a significant step in the development of novel and effective antimicrobial drugs capable of overcoming the growing threat of antibiotic resistance and aiding in the fight against infectious diseases.

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About the authors

A. G. Volkov

Perm State Medical University named after Academician E. A. Wagner; Perm National Research Polytechnic University

Author for correspondence.
Email: 89991266866@mail.ru

Ph.D. (Medical), Senior Lecturer of Pharmacology Department; Associate Professor of Environmental Protection Department

Russian Federation, Perm; Perm

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