Combined method for quality control of colloidal silver
- Authors: Kolyabina E.S.1, Maksimova T.V.1
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Affiliations:
- Peoples' Friendship University of Russia
- Issue: Vol 26, No 9 (2023)
- Pages: 48-51
- Section: Pharmaceutical chemistry
- URL: https://journals.eco-vector.com/1560-9596/article/view/601802
- DOI: https://doi.org/10.29296/25877313-2023-09-07
- ID: 601802
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Abstract
Relevance. Silver nanoparticles are interesting as an alternative to antibiotics and as their carrier. Bioavailability of silver is affected by particle size, morphology, and concentration. The studied combination of methods is promising for the rapid detection of technological defects in production and the fight against counterfeiting.
Objective. To develop a combined method for quality control of silver-containing colloidal solutions. This method in addition to elemental determination will consider the disperse characteristics of particles.
Material and methods. Four silver-containing preparations were studied: ProtargolLor (P.J.S.C. “Pharmstandard”, Kursk); Argitos colloidal silver (“Nanosphere”, Russia), Argent Colloidal (Nutri expert, France); Granions d’Argent (Laboratoire des Granions Le Mercator, France). The study was carried out using Energy dispersive spectrometer Shimadzu EDX-7000 (Japan), Laser hydrodynamic particle size analyzer Zetasizer (Malvern Instruments, UK).
Results. In this article we propose the use of a combined method for the quality control of silver-containing preparations. The express X-ray fluorescence method is supplemented by the method of dynamic laser light scattering. This combined method allows to determine the composition and size spectra of the particles of the studied samples. It will significantly reduce costs and protect the laborants from the toxic effects of reagents used for mineralization.
Conclusion. The combination of disperse and elemental analysis methods is promising for quality control of silver-containing pharmaceuticals. This technology will detect counterfeit and manufacturing defects.
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About the authors
E. S. Kolyabina
Peoples' Friendship University of Russia
Author for correspondence.
Email: kolyabina.ks@gmail.com
Post-graduate Student, Department of Pharmaceutical and Toxicological Chemistry, Medical Institute
Russian Federation, MoscowT. V. Maksimova
Peoples' Friendship University of Russia
Email: kolyabina.ks@gmail.com
Ph.D. (Pharm.), Associate Professor, Department of Pharmaceutical and Toxicological Chemistry, Medical Institute
Russian Federation, MoscowReferences
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