Assessment of antioxidant, hypoglycemic and hypolypidemic activities of the herbal extract of hill-growing saltwort (Salsola collina)
- Authors: Korotchenko N.V.1, Sergun V.P.2, Ivanov A.A.2, Burkova V.N.2, Samoylova Y.G.3
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Affiliations:
- Tomsk Regional Center for the Prevention and Control of AIDS and Other Infectious Diseases
- "Biolit" LLC
- Siberian State Medical University
- Issue: Vol 27, No 9 (2024)
- Pages: 57-64
- Section: Medical chemistry
- URL: https://journals.eco-vector.com/1560-9596/article/view/636230
- DOI: https://doi.org/10.29296/25877313-2024-09-08
- ID: 636230
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Abstract
Introduction. The development of safe and effective natural antioxidant drugs is an important task in the prevention and treatment of cardiovascular diseases, which are a serious public health problem.
Work Objective is a study of the antioxidant, hypoglycemic and hypolipidemic activities of the herbal extract of hill-growing saltwort (Salsola collina) in comparison with the effect of a standard antioxidant agent.
Material and methods. The object of the study was a "Hepatosol" biologically active food supplement based on a dry concentrated aqueous extract of the Salsola collina herb in capsules.
The patients under observation were matched groups of obese women and men of comparable age with risk factors for cardiovascular diseases. During the study, tolerability and possible adverse events were recorded and vital signs were monitored. The results of a biochemical blood test, lipid profile, oxidative stress and body composition analysis of patients were also evaluated and interpreted.
Results. It has been found out that the parameters of the lipid profile and antioxidant status in patients with obesity and a risk of cardiovascular complications taking the herbal extract of hill-growing saltwort for 3 months returned to normal. A hypoglycemic positive effect of the herbal extract of hill-growing saltwort on reducing the body weight of patients has been recorded. The safety and good tolerability of the study drug have been confirmed.
Conclusions. The results of studies show that a biologically active food supplement "Hepatosol" based on the extract of the Salsola collina herb has antioxidant, hypoglycemic and hypolipidemic activities. Due to these properties, the drugs based on a dry concentrated aqueous extract of the Salsola collina herb are favorable for diet therapy of patients with diabetes mellitus, for weight loss and use in the prevention and complex therapy of cardiovascular diseases.
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About the authors
N. V. Korotchenko
Tomsk Regional Center for the Prevention and Control of AIDS and Other Infectious Diseases
Email: infobiolit@yandex.ru
ORCID iD: 0009-0000-0978-1999
Infectious Disease Doctor
Russian Federation, 5a Smirnova st., Tomsk, 634059V. P. Sergun
"Biolit" LLC
Email: infobiolit@yandex.ru
ORCID iD: 0009-0003-6368-9992
Ph. D. (Chem.), Director
Russian Federation, 4 bilding 3, Akademichesky Ave, Tomsk, 634055A. A. Ivanov
"Biolit" LLC
Author for correspondence.
Email: infobiolit@yandex.ru
ORCID iD: 0009-0004-4321-388X
Ph. D. (Chem.), Head of Research Department
Russian Federation, 4 bilding 3, Akademichesky Ave, Tomsk, 634055V. N. Burkova
"Biolit" LLC
Email: infobiolit@yandex.ru
ORCID iD: 0009-0003-4253-4764
Dr. Sc. (Chem.), Director of Science and Innovation
Russian Federation, 4 bilding 3, Akademichesky Ave, Tomsk, 634055Yu. G. Samoylova
Siberian State Medical University
Email: infobiolit@yandex.ru
ORCID iD: 0000-0002-2667-4842
Dr. Sc. (Med.), Professor, Department of Endocrinology and Diabetology
Russian Federation, Main Building 2, Moskovsky trakt, 634050, TomskReferences
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