Current status and the perspectives of follow-up study of spanish salsify (survey)


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Abstract

A potential antidepressant based on the BDNF loop 4 dipeptide mimetic GSB-106, bis-(N-monosuccinyl-L-seryl-L-lysine) hexameth-ylenediamide, is developing at the V.V. Zakusov Research Institute of Pharmacology.It is well known that depression is often accompanied by cognitive impairment. The aim of this investigation was to study the nootropic activity of GSB-106. The effect of GSB-106 dipeptide on memory was studied upon subchronicintraperitoneal (ip) administration to unbred male ratsusing novel object recognition testand passive avoidance reflex amnesia caused by maximum electroshock (MES).GSB-106 was administered at a dose of 0.1 mg/kg (ip) for 14 days before the object recognition test and at doses of 0.1 and 1.0 mg/kg (ip) for 5 days before passive avoidance reaction training. It was found that GSB-106 at a dose of 0.1 mg / kg improves working memory in the novel object recognition test, increasing the relative time of investigation of an unfamiliar object, and at a dose of 1.0 mg / kg shows a pronounced antiamnestic activity with a therapeutic effect of about 60% in the passive avoidance reaction test with amnesia caused by MES. Thus, the dipeptide mimetic of the BDNF loop 4 GSB-106 exhibits nootropic activity.

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About the authors

P. Yu Povarnina

V.V. Zakusov Research Institute of Pharmacology

Email: povarnina@gmail.com

D. M Nikifiriv

V.V. Zakusov Research Institute of Pharmacology

S. O Kotelnikova

V.V. Zakusov Research Institute of Pharmacology

V. A Kraineva

V.V. Zakusov Research Institute of Pharmacology

T. A Guydasheva

V.V. Zakusov Research Institute of Pharmacology

S. B Seredenin

V.V. Zakusov Research Institute of Pharmacology

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