Patterns of hair mineral and trace element contents in children with Down’s syndrome and mental retardation
- Authors: Grabeklis A.R1,2, Skalnaya A.A3, Mazaletskaya A.L4, Ajsuvakova O.P5
-
Affiliations:
- I.M. Sechenov First Moscow State Medical University
- Peoples' Friendship University of Russia
- Research Center of Neurology
- Yaroslavl State University
- Micronutrients JSC
- Issue: Vol 23, No 11 (2020)
- Pages: 34-39
- Section: Articles
- URL: https://journals.eco-vector.com/1560-9596/article/view/112797
- DOI: https://doi.org/10.29296/25877313-2020-11-06
- ID: 112797
Cite item
Open Access
Access granted
Abstract
Relevance. Down's syndrome is a genetic disorder caused by trisomy of chromosome 21. It manifests itself in a wide range of symptoms, including neuropsychiatric disorders, which may be partly due to disturbed metabolism of essential metals in the body. Objective. To study the content of essential minerals and trace elements in hair of children with Down's syndrome and mental retardation in order to find possible common patterns. Material and methods. The study involved 109 children with mental retardation, 75 children with Down's syndrome, and 107 healthy children aged 1 to 7 years (3.28 ± 1.88 years).Co, Cr, Cu, Fe, I, Li, Mn, Se, V, Zn, Ca, K, Mg, Na, Pw as guantitatively determined in hair by inductively coupled plasma mass spectrometry (ICP-MS). Results. The content of cobalt, copper, iron, selenium and vanadium in hair of children with mental retardation and Down's syndrome was lower than in control group by 12% and 11%, 8% and 11%, 18% and 16%, 36% and 15%, 47% and 34%, respectively. At the same time, the level of chromium, lithium, manganese, and zinc as compared to the control group was lower only in children with mental retardation, by 21%, 22%, 11% and 27%, respectively. In children with Down's syndrome the iodine level exceeded the control values by 54%, though in children with mental retardation such differences were not revealed. The phosphorus content in children with mental retardation and Down's syndrome was lower and higher than the control values by 8% and 24%, respectively. The magnesium content in the hair of children with mental retardation was lower than that in healthy subjects and children with Down's syndrome by 18% and 13%, respectively.Allthementioneddifferenceswerestatisticallysignificant (p < 0.05). Conclusion. There are a number of common patterns in altered metabolism of essential minerals and trace elements in children with Down's syndrome and mental retardation. Despite the undoubtedly genetic cause of pathological changes in Down's disease, these al terations can partially cause neuropsychiatric disorders observed in Down's syndrome patients.
Keywords
Full Text
About the authors
A. R Grabeklis
I.M. Sechenov First Moscow State Medical University; Peoples' Friendship University of Russia
Email: andrewgrabeklis@gmail.com
Ph.D. (Biol.), Senior Research Scientist, I.M. Sechenov First Moscow State Medical University; Senior Lecturer, Peoples' Friendship University of Russia (Moscow) Moscow
A. A Skalnaya
Research Center of NeurologyResident Physician Moscow
A. L Mazaletskaya
Yaroslavl State UniversityPh.D. (Psych.) Yaroslavl
O. P Ajsuvakova
Micronutrients JSCPh.D. (Chem.), Chemist Moscow
References
- Janka Z. Tracing trace elements in mental functions. Ideggyogyaszatiszemle. 2019; 72(11-12):367-379. doi: 10.18071/isz.72.0367.
- Saghazadeh A., Mahmoudi M., Dehghani Ashkezari A., Oliaie Rezaie N., Rezaei N. Systematic review and meta-analysis shows a specific micronutrient profile in people with Down Syndrome: Lower blood calcium, selenium and zinc, higher red blood cell copper and zinc, and higher salivary calcium and sodium. PLoS One. 2017; 12(4):є0175437. doi: 10.1371/journal.pone.0175437.
- Törsdöttir G., Kristinsson J., Hreidarsson S., Snaedal J., Johannesson T. Copper, ceruloplasmin and superoxide dismutase (SOD1) in patients with Down's syndrome. Pharmacol. Toxicol. 2001; 89(6):320-325. doi: 10.1034/j.1600-0773.2001.d01-168.x.
- Mazurek D., Wyka J. Down syndrome--genetic and nutritional aspects of accompanying disorders. Rocz. Panstw. Zakl. Hig. 2015; 66(3): 189-194.
- Grabeklis A.R., Skalny A.V., Ajsuvakova O.P., Skalnaya A.A., Mazaletskaya A.L., Klochkova S.V., Chang S.J.S., Nikitjuk D.B., Skalnaya M.G., Tinkov A.A. A Search for Similar Patterns in Hair Trace Element and Mineral Content in Children with Down's Syndrome, Obesity, and Growth Delay. Biol. Trace Elem. Res. 2020; 196(2):607-617. doi: 10.1007/s1201 1-019-01938-6.
- Malakooti N., Pritchard M.A., Adlard P.A., Finkelstein D.I. Role of metal ions in the cognitive decline of Down syndrome. Front. Aging Neurosci. 2014; 6:136. doi: 10.3389/fnagi.2014.00136.
- Magenis M.L., Machado A.G., Bongiolo A.M., Silva M.A.D., Castro K., Perry I.D.S. Dietary practices of children and adolescents with Down syndrome. J. Intellect. Disabil. 2018; 22(2):125-134. doi: 10.1177/1744629516686571.
- Lutsenko S. Sending copper where it is needed most. Science. 2020; 368(6491): 584-585. doi: 10.1126/science.abb6662.
- Georgieff M.K. Iron assessment to protect the developing brain. Am. J. Clin. Nutr. 2017; 106(Suppl 6):1588S-1593S. doi: 10.3945/ajcn.117.155846.
- Pillai R., Uyehara-Lock J.H., Bellinger F.P. Selenium and selenoprotein function in brain disorders. IUBMB Life. 2014; 66(4):229-239. doi: 10.1002/iub.1262.
- Hart S.J., Zimmerman K., Linardic C.M., Cannon S., Pastore A., Patsiogiannis V., Rossi P., Santoro S.L., Skotko B.G., Torres A., Valentini D., Vellody K., Worley G., Kishnani P.S. Detection of iron deficiency in children with Down syndrome. Genet. Med. 2020; 22(2):317-325. doi: 10.1038/s41436-019-0637-4.
- Dai Y., Li W., Zhong M., Chen J., Cheng Q., Liu Y., Li T. The paracrine effect of cobalt chloride on BMSCs during cognitive function rescue in the HIBD rat. Behav. Brain Res. 2017; 332:99-109. doi: 10.1016/j.bbr.2017.05.055.
- Ahmadi-Eslamloo H., Dehghani G.A., Moosavi S.M.S. Long-term treatment of diabetic rats with vanadyl sulfate or insulin attenuate acute focal cerebral ischemia/reperfusion injury via their antiglycemic effect. Metab. Brain Dis. 2018; 33(1):225-235. doi: 10.1007/s11011-017-0153-7.
- Portbury S.D., Adlard P.A. Zinc Signal in Brain Diseases. Int. J. Mol. Sci. 2017; 18(12):2506. doi: 10.3390/ijms18122506.
- Kirkland A.E., Sarlo G.L., Holton K.F. The Role of Magnesium in Neurological Disorders. Nutrients. 2018; 10(6):730. doi: 10.3390/nu10060730.
- Goday-Arno A., Cerda-Esteva M., Flores-Le-Roux J.A., Chillaron-Jordan J.J., Corretger J.M., Cano-Perez J.F. Hyperthyroidism in a population with Down syndrome (DS). Clin. Endocrinol. (Oxf). 2009; 71(1): 110-114. doi: 10.1111/j.1365-2265.2008.03419.x.
- Li L., Zhi M., Hou Z., Zhang Y., Yue Y., Yuan Y. Abnormal brain functional connectivity leads to impaired mood and cognition in hyperthyroidism: a resting-state functional MRI study. Oncotarget. 2017; 8(4):6283-6294. doi: 10.18632/on-cotarget.14060.
- Lamberg-Allardt C., Kemi V. Interaction Between Calcium and Phosphorus and the Relationship to Bone Health. In: Clinical Aspects of Natural and Added Phosphorus in Foods. Springer, New York, NY. 2017. P. 145-157.
- Gonzalez-Agüero A., Vicente-Rodriguez G., Moreno L.A., Casajus J.A. Bone mass in male and female children and adolescents with Down syndrome. Osteoporos. Int. 2011; 22(7):2151-2157. doi: 10.1007/s00198-010-1443-7.
Supplementary files
