Immunomodulating properties of the complex plant supplement «Gipeliv»

A necessity in finding new hepatoprotective drugs and supplements is dictated by the growing demand: increasingly widespread liver pathologies tending to chronic forms being caused by viruses, toxic agents including some medication. The aim of the work was to determine immunomodulating properties of the complex plant supplement consisting of Hypecoum erectus L, Hedysarum dauricum, Glycyrhhiza uralensis Fisch., Calendula officinalis and Scutellaria baicalensis. The effect of the studied plant supplement was measured by assessement of cellular, humoral and macrophageal components of immune response in the mouse model of azathioprine induced immunodeficiency. The experiment was carried out on male FI line mice (CBAxC57BI/6). Immunosuppressive agent azathioprine was administered to the control group of animals 50 mg/kg orally once daily during 5 days. The experimental group received same doses of azathioprine and the plant supplement 100 mg/kg once daily for 14 days. The state of the cellular component of the immune response was evaluated by following the standard method of the delayed-type hypersensitivity reaction (DTH) assessment, while the macrophage component was studied in the reaction of phagocytosis of peritoneal macrophages, and the assessment of humoral immunity was measured by the number of antibody-forming cells.

immunomodulating properties, complex plant supplement, cellular immunity, humoral immunity, macrophages