Scientific and methodological approach to the choice of polymeric materials for tissue therapy
- Authors: Kuznetsov А.О.1, Zuryanov О.A.1, Marshalova М.М.1, Migalyev D.A.1, Brkich G.E.1, Pyatigorskaya N.V.1
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Affiliations:
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- Issue: Vol 28, No 3 (2025)
- Pages: 21-28
- Section: Pharmaceutical chemistry
- URL: https://journals.eco-vector.com/1560-9596/article/view/677701
- DOI: https://doi.org/10.29296/25877313-2025-03-03
- ID: 677701
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Abstract
Introduction. The idea of using polymeric compositions in medicine that can modulate regeneration phases and directly influence them in order to improve the potential of recovery has found its application in the development of polymer-based compositions for the treatment of tissue damage. A wide range of polymers of natural and synthetic origin allows one to select the composition of the polymer composition or additionally chemically modify it to impart new properties to the material. Currently created wound dressings often do not always allow achieving the expected therapeutic effects, so the task of creating new polymeric compositions is relevant and of great interest in medical society.
The aim of this study is to develop a scientific and methodological approach to expanding the range of polymeric materials for the therapy of wound surfaces.
Material and methods. The development of a scientific and methodological approach for an objective assessment of the prospects for creating polymeric materials for the therapy of wound surfaces was carried out using information retrieval databases (ScienceDirect, Wiley Online Library, PubMed).
Results. Based on the results of the study of information retrieval and library databases, it was found that the main problem arising in the development of polymer compositions is adhesion - the total surface area of the drug contact with the wound increases the effectiveness of therapy due to the complex effect on the entire wound bed. The key parameter in this case is adhesion - the phenomenon of interaction between dissimilar bodies during their intermolecular contact. Polymer compositions can be used to significantly increase the efficiency of regeneration, as well as to create optimal conditions in the wound microenvironment and protection from additional external influences. Biopharmaceutical features and main functional groups of polymeric materials were considered, which should be taken into account when choosing a composition for creating polymer compositions.
Conclusion. The development of a scientific and methodological approach for an objective assessment of the prospects for creating polymeric materials for the therapy of wound surfaces made it possible to formulate the main properties that should be taken into account when choosing the composition of the polymer composition to create a finished product in the therapy of wound surfaces at various stages of healing.
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About the authors
А. О. Kuznetsov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: chem.kuznetzov@gmail.com
ORCID iD: 0009-0009-2125-1101
SPIN-code: 9437-1452
Master's, Department of Industrial Pharmacy
Russian Federation, st. Trubetskaya, 8, p. 2, Moscow, 119048О. A. Zuryanov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: chem.kuznetzov@gmail.com
ORCID iD: 0000-0001-9038-8720
SPIN-code: 7658-8201
Ph.D. (Pharm.), Associate Professor, Department of Industrial Pharmacy
Russian Federation, st. Trubetskaya, 8, p. 2, Moscow, 119048М. М. Marshalova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: chem.kuznetzov@gmail.com
ORCID iD: 0000-0002-5281-7771
SPIN-code: 9259-3048
Senior Lecturer, Department of Industrial Pharmacy
Russian Federation, st. Trubetskaya, 8, p. 2, Moscow, 119048D. A. Migalyev
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: chem.kuznetzov@gmail.com
ORCID iD: 0009-0004-0938-9195
SPIN-code: 8017-0006
Post-graduate Student
Russian Federation, st. Trubetskaya, 8, p. 2, Moscow, 119048G. E. Brkich
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: chem.kuznetzov@gmail.com
ORCID iD: 0000-0002-3469-9062
SPIN-code: 6677-0344
Dr.Sc. (Pharm.), Professor, Department of Industrial Pharmacy
Russian Federation, st. Trubetskaya, 8, p. 2, Moscow, 119048N. V. Pyatigorskaya
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: chem.kuznetzov@gmail.com
ORCID iD: 0000-0003-4901-4625
SPIN-code: 8128-1725
Dr.Sc. (Pharm.), Corresponding Member, Russian Academy of Sciences, Head of the Department of Industrial Pharmacy
Russian Federation, st. Trubetskaya, 8, p. 2, Moscow, 119048References
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