MIDAZOLAM MICROENCAPSULATION AS A METHOD OF MODIFYING ITS PHARMACOKINETICS
- 作者: Judin M.A1, Chepur S.V1, Aleshina O.I1, Bykova A.F1, Ivanov I.M1
-
隶属关系:
- Federal State Budgetary Institution State Scientific-Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation
- 期: 卷 22, 编号 8 (2019)
- 页面: 27-32
- 栏目: Articles
- URL: https://journals.eco-vector.com/1560-9596/article/view/112665
- DOI: https://doi.org/10.29296/25877313-2019-08-05
- ID: 112665
如何引用文章
开放存取
##reader.subscriptionAccessGranted##
详细
Purpose of the study. The selection of the most optimal method for obtaining the microencapsulated form of midazolam, which improves the kinetics of its release from microparticles. Materials and methods. Methods of emulsification, double emulsification, nanoprecipitation and spray drying were used to create a microencapsulated form of midazolam. The efficiency of incorporation and distribution of midazolam between the matrix and the surface of the particles was evaluated using the HPLC methods. Results. It's shown that the application of the spray drying method provides the maximum inclusion of midazolam in polymer matrices for samples based on alginate (more than 44 %) and polylactide-co-glicolide (more than 60 %). The in vitro release kinetics of midazolam is characterized by a gentle curve for sodium alginate-based samples compared to polylactide-co-glicolide samples. Findings. The most optimal midazolam incorporation and release parameters are achieved using PLGA- and alginate-based polymeric matrices. This allows us to consider samples based on them as promising means to increase the anticonvulsant effect in the treatment of toxic convulsive syndrome.
全文:
作者简介
M. Judin
Federal State Budgetary Institution State Scientific-Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian FederationDr.Sc. (Med.), Associate Professor, Head of Department St. Petersburg
S. Chepur
Federal State Budgetary Institution State Scientific-Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian FederationDr.Sc. (Med.), Professor, Head St. Petersburg
O. Aleshina
Federal State Budgetary Institution State Scientific-Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian FederationJunior Research Scientist St. Petersburg
A. Bykova
Federal State Budgetary Institution State Scientific-Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation
Email: anna-kurpyakova@rambler.ru
Ph.D. (Biol.), Senior Research Scientist St. Petersburg
I. Ivanov
Federal State Budgetary Institution State Scientific-Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian FederationPh.D. (Med.), Deputy Head of Department St. Petersburg
参考
- Jellinger K.A. The human nervous system structure and function // European Journal of Neurology. 2009; 45 (7): 136-136.
- Rongen V. A., Vaughns J.D., Moorthy G.S. et al. Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents // Br. J. Clin. Pharmacol. 2015; 80 (5): 1185-1196.
- Singh R., Lillard J.W. Nanoparticle-based targeted drug delivery // Experimental and Molecular Pathology. 2009; 86 (3): 215-223.
- Sharma D., Gabrani R., Sharma S.K. et al. Development of midazolam loaded poly(d,l-lactide-co-glycolic acid) nanoparticles for treatment of status epilepticus // Advanced Science Letters. 2014; 20 (7): 1526-1532.
- Daemi H., Barikani M. Synthesis and characterization of calcium alginate nanoparticles, sodium homopolymannuronate salt and its calcium nanoparticles // Scientia Iranica. 2012; 19 (6): 2023-2028.
- Venkata B.V., Maulick C. Emil J. Sonal M. Preparation and characterization of nanoparticles of carboxymethyl cellulose acetate butyrate containing acyclovir // Applied Nanoscience. 2016; 6 (2): 197-208.
- Sarfaraz M.D., Hiremath D, Chowdary K.P.R. Formulation and characterization of rifampicin microcapsules // Indian Journal of Pharmaceutical Sciences. 2010; 72 (1): 101-105.
- Sagiri S.S., Pal K., Basak P. et al. Encapsulation of sorbitan ester-based organogels in alginate microparticles // AAPS PharmSciTech. 2014; 15 (15): 1197-1208.
- Attia M.I., Eldehna W.M., Afifi S.A. et al. New hydrazonoindolin-2-ones: synthesis, exploration of the possible antiproliferative mechanism of action and encapsulation into PLGA microspheres // PloS One. 2017; 12(7): 1-24.
- Do A.V., Geary S.M., Seol D. et al. Combining ultrasound and intratumoral administration of doxorubicin-loaded microspheres to enhancer tumor cell killing // Int. J. Pharm. 2018; 539 (1-2): 139-146.
- Jaswir I., Noviendri D., Taher M. et al. Optimization and formulation of fucoxanthin-loaded microsphere (F-LM) using response surface methodology (RSM) and analysis of its fucoxanthin release profile // Molecules. 2019; 24 (5): 947-963.
补充文件
