Prospects for applications of nanodiamonds in medicine (review)


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Nowadays, detonation nanodiamonds are considered by researchers as promising nanocarriers in the fields of biologically active substances and drug delivery systems. The possibility of using detonation nanodiamonds in biomedicine is due to the presence of a set of unigue physicochemical properties, namely: nanodiamonds have a large specific surface area, stable fluorescence, biocompatibility, the ability to adsorb or conjugate with drugs. These properties of detonation nanodiamonds determine their use to create biomarkers, biosensors, highly effective adsorbents, catalysts for deactivation of toxins, dental composite materials. The procedure for standardisation and unification of industrially produced detonation nanodiamonds significantly expands the prospects for their application in medicine. The purpose of this review is to analyse the works of domestic and foreign scientists, which consider the use of detonation nanodiamonds not only as nanocarriers in delivery systems of cytostatics for the treatment of cancer, but also for the targeted delivery of a number of drugs for the treatment of other pathologies. The review article will be useful for specialists working in the field of nanomedicine and nanoengineering.

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作者简介

G. Berdichevskiy

Pavlov First Saint Petersburg State Medical University

Email: grishaberd@gmail.com
Post-graduate Student Department of Biological Chemistry Saint Petersburg

L. Vasina

Pavlov First Saint Petersburg State Medical University

Email: lubov.vasina@gmail.com
Dr.Sc. (Med.), Head of the Department of Biological Chemistry Saint Petersburg

E. Ryumina

Pavlov First Saint Petersburg State Medical University

Email: evrumina2@mail.ru
Department of Biological Chemistry Saint Petersburg

V. Sharoyko

Pavlov First Saint Petersburg State Medical University

Email: sharoyko@gmail.com
Department of General and Bioorganic Chemistry Saint Petersburg

K. Semenov

Pavlov First Saint Petersburg State Medical University

Email: knsemenov@gmail.com
Dr.Sc. (Chem.), Head of the Department of General and Bioorganic Chemistry Saint Petersburg

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