Prospects for applications of nanodiamonds in medicine (review)


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Nowadays, detonation nanodiamonds are considered by researchers as promising nanocarriers in the fields of biologically active substances and drug delivery systems. The possibility of using detonation nanodiamonds in biomedicine is due to the presence of a set of unigue physicochemical properties, namely: nanodiamonds have a large specific surface area, stable fluorescence, biocompatibility, the ability to adsorb or conjugate with drugs. These properties of detonation nanodiamonds determine their use to create biomarkers, biosensors, highly effective adsorbents, catalysts for deactivation of toxins, dental composite materials. The procedure for standardisation and unification of industrially produced detonation nanodiamonds significantly expands the prospects for their application in medicine. The purpose of this review is to analyse the works of domestic and foreign scientists, which consider the use of detonation nanodiamonds not only as nanocarriers in delivery systems of cytostatics for the treatment of cancer, but also for the targeted delivery of a number of drugs for the treatment of other pathologies. The review article will be useful for specialists working in the field of nanomedicine and nanoengineering.

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作者简介

G. Berdichevskiy

Pavlov First Saint Petersburg State Medical University

Email: grishaberd@gmail.com
Post-graduate Student Department of Biological Chemistry Saint Petersburg

L. Vasina

Pavlov First Saint Petersburg State Medical University

Email: lubov.vasina@gmail.com
Dr.Sc. (Med.), Head of the Department of Biological Chemistry Saint Petersburg

E. Ryumina

Pavlov First Saint Petersburg State Medical University

Email: evrumina2@mail.ru
Department of Biological Chemistry Saint Petersburg

V. Sharoyko

Pavlov First Saint Petersburg State Medical University

Email: sharoyko@gmail.com
Department of General and Bioorganic Chemistry Saint Petersburg

K. Semenov

Pavlov First Saint Petersburg State Medical University

Email: knsemenov@gmail.com
Dr.Sc. (Chem.), Head of the Department of General and Bioorganic Chemistry Saint Petersburg

参考

  1. Mendes R.G., Wrobel P.S., Bachmatiuk A., Sun J., Gemming T., Liu Z., Rummeli M.H. Carbon nanostructures as multifunctional drug delivery platforms. J. Mater. Chem. B. 2013; 1(4): 401-428.
  2. Яковлев Р.Ю., Кулакова И.И., Бадун Г.А., Лисичкин Г.В., Валуева А.В., Селезнев Н.Г., Леонидов Н.Б. Физико-химические принципы получения и свойства гибридных материалов на основе детонационных наноалмазов как систем доставки лекарственных веществ нового поколения. Разработка и регистрация лекарственных средств. 2016; 3(16): 60-66.
  3. Shenderova O.A., McGuire G.E. Science and engineering of nanodiamond particle surfaces for biological applications (Review). Biointerphases. 2015; 10(3): 30802.
  4. Яковлев Р.Ю., Соломатин А.С., Леонидов Н.Б., Кулакова И.И., Лисичкин Г.В. Детонационный наноалмаз - перспективный носитель для создания систем доставки лекарственных веществ. Российский химический журнал. 2012; 56(3-4): 114-125
  5. Shenderova O.A., Gruen D.M. Ultra nanocrystal line diamond synthesis, properties and applications. Ed. by Norwich, New York: William Andrew Publishing. 2006; с. 333-404.
  6. Кулакова И.И., Корольков В.В., Яковлев Р.Ю., Лисичкин Г.В. Строение частиц химически модифицированного наноалмаза детонационного синтеза. Российские нанотехнологии. 2010; 5(7-8): 66-73.
  7. Badun G.A., Chernycheva M.G., Yakovlev R.Y., Leonidov N.B., Semenenko M.N., Lisichkin G.V. A novel approach radiolabeling detonation nanodiamonds through the tritium thermal activation method. Radiochimica Acta. 2015; 102(10): 941-946.
  8. Yakovlev R.Y., Alieva I.B., Leonidov N.B., Rakita D.R., Agafonov V.N., Uzbekov R.E. Interaction dynamics of the nanodiamond with living cells in culture. In Book of Abstract Int. Conf. Advanced Carbon Nanostructures (ACNS). St.-Petersburg, 2011; с. 206.
  9. Horie M., Komaba L.K., Kato H., Nakamura A., Yamamoto K., Endoh S., Fujita K., Kinugasa S., Mizuno K., Hagihara Y., Yoshida Y., Iwahashi H. Evaluation of cellular influences induced by stable nanodiamond dispersion; the cellular influences of nanodiamond are small. Diamond and Related Materials. 2012; 24: 15-24.
  10. Solarska K., Gajewska A., Kaczorowski W., Bartosz G., Mitura K. Effect of nanodiamond powders on the viability and production of reactive oxygen and nitrogen species by human endothelial cells. Diamond and Related Materials. 2012; 21: 107-113.
  11. Жуков Е.Л., Медведева Н.Н. Реакция внутренних органов кроликов на внутривенное введение наноалмазов // Современные проблемы науки и образования. 2015; 6: 1-8.
  12. Медведева Н.Н., Жуков Е.Л. Результаты действия наноалмазов и эетеросорбентов на организм экспериментальных животных. Вестник КрасГАУ. Ветеринария. 2010; 2: 93-96.
  13. Пузырь А.П., Буров А.Е., Бондарь В.С., Трусов Ю.Н. Нейтрализация афлатоксина В1 озонированием и адсорбцией наноалмазами. Российские нанотехнологии. 2010; 5: 122-125.
  14. Патент № 2538611 (РФ). Способ определения биологической неэквивалентности наноалмазов. Соломатин А.С., Яковлев Р.Ю., Федотчева Н.И., Кондрашова М.Н., Леонидов Н.Б. 2013.
  15. Соломатин А.С., Яковлев Р.Ю., Леонидов Н.Б., Бадун Г.А., Чернышева М.Г., Кулакова И.И., Ставрианиди А.Н., Шляхтин О.А., Лисичкин Г.В. Получение меченного тритием амикацина и его сорбционная иммобилизация на функционализированных наноалмазах. Вестник Московского университета. Сер. 2. Химия. 2018; 59(3): 179-181.
  16. Chernysheva M.G., Myasnikov I.Yu, Badun G.A. Myramistin adsorption on detonation nanodiamonds in the development of drug delivery platforms. Diamond and Related Materials. 2015; 55: 45-51.
  17. Патент № 2506074 (РФ). Антигипоксант и способ его получения. Леонидов Н.Б., Яковлев Р.Ю., Кулакова И.И., Лисичкин Г.В. 2014.
  18. Chen M., Pierstorff E.D., Lam R., Li S.Y., Huang H., Osawa E., Ho D. Nanodiamond-mediated delivery of water-insoluble therapeutics. ACS Nano. 2009; 3(7): 2016-2022.
  19. Chow E.K., Zhang X.Q., Chen M., Lam R., Robinson E., Huang H., Schaffer D., Osawa E., Goga A., Ho D. Nanodiamond therapeutic delivery agents mediate enhanced che-moresistant tumor treatment. Sci. Trans. Med. 2011; 3: 73.
  20. Yuan S.J., Xu Y.H., Wang C., An H.C., Xu H.Z., Li K., Komatsu N., Zhao L., Chen X. Doxorubicin-polyglycerol-nanodiamond conjugate is a cytostatic agent that evades chemoresistance and reverses cancer-induced immunosuppression in triple-negative breast cancer. J. Nanobiotechnology. 2019; 17: 110
  21. Li T.F., Xu Y.H., Li K., Wang C., Liu X., Yue Y., Chen Z., Yuan S.J., Wen Y., Zhang Q., Han M., Komatsu N., Zhao L., Chen X. Doxorubicin-polyglycerol-nanodiamond composites stimulate glioblastoma cell immunogenicity through activation of autophagy. Acta Biomater. 2019; 86: 381-94.

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