Polymorphisms of genes associated with psycho-emotional deviations in a sample of healthy male conscripts
- Authors: Malyshkin S.S.1, Krivoruchko A.B.2, Kutelev G.G.2, Koreshova E.I.2, Kalyuzhnaya O.V.1, Shapoval R.M.1, Derevyankin D.S.1, Zhurbin E.A.1, Potapov P.K.1
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Affiliations:
- Military Innovation Technopolis "ERA"
- Military Medical Academy of S.M. Kirov
- Issue: Vol 24, No 2 (2022)
- Pages: 299-306
- Section: Research paper
- Submitted: 21.03.2022
- Accepted: 07.05.2022
- Published: 13.07.2022
- URL: https://journals.eco-vector.com/1682-7392/article/view/105178
- DOI: https://doi.org/10.17816/brmma105178
- ID: 105178
Cite item
Abstract
The prevalence of candidate gene polymorphic alleles associated with personality disorders was studied in a sample of healthy male Military Innovation Technopolis «ERA» recruits, science mouth operators of Caucasian race aged 23–27 (median age 24). Genotyping of 10 studied polymorphic variants of genes was carried out using polymerase chain reaction in real time. According to the results, the distribution of genotypes in the studied group of single nucleotide polymorphisms corresponded to Hardy–Weinberg equilibrium, except for the C677T MTHFR variant (rs1801133). The occurrence of minor alleles was as follows: 0.500 for A1438G and 0.310 for C102T (HTRA2); 0.175 for G-6A (CNTF); 0.508 for C > T (UCP2); 0.270 for A1298C and 0.325–C677T (MTHFR); 0.278–A2756G (MTR); 0.571–A66G (MTRR); 0.381–Alu Ins/Del (ACE); 0.294–G1444A (PPARGC1A). In the studied sample, the frequency of occurrence of minor alleles of 10 genetic markers correlated with data collected on people of European descent. The greatest statistical deviation was observed by comparison with data on people of African descent. Statistically significant concordances with different populations and studies conducted in them are the basis for including the selected polymorphisms in a candidate list of psycho-emotional and neurological pathologies influencing the occupational fitness of servicepersons. However, reliable data on the association between mental disorders and the development of degenerative disorders are not available simultaneously in all populations; therefore, additional research is required on this subject.
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About the authors
Svyatoslav S. Malyshkin
Military Innovation Technopolis "ERA"
Author for correspondence.
Email: svytoslavmal@gmail.com
ORCID iD: 0000-0003-4366-0028
SPIN-code: 8109-3446
Master
Russian Federation, AnapaAlexander B. Krivoruchko
Military Medical Academy of S.M. Kirov
Email: krab25@mail.ru
ORCID iD: 0000-0003-2035-4888
SPIN-code: 1324-0239
Candidate of Medical Sciences
Russian Federation, Saint PetersburgGennady G. Kutelev
Military Medical Academy of S.M. Kirov
Email: gena08@yandex.ru
ORCID iD: 0000-0002-6489-9938
SPIN-code: 5139-8511
Candidate of Medical Sciences
Russian Federation, Saint PetersburgElena I. Koreshova
Military Medical Academy of S.M. Kirov
Email: Koreshova1993@mail.ru
SPIN-code: 5310-0605
Master
Russian Federation, Saint PetersburgOlga V. Kalyuzhnaya
Military Innovation Technopolis "ERA"
Email: Ioj2004@mail.ru
ORCID iD: 0000-0002-3845-6375
SPIN-code: 1755-1405
Candidate of Biological Sciences
Russian Federation, AnapaRoman M. Shapoval
Military Innovation Technopolis "ERA"
Email: SHAP0VAL.R@yandex.ru
ORCID iD: 0000-0001-6871-1448
SPIN-code: 6114-7705
Bachelor
Russian Federation, AnapaDmitry S. Derevyankin
Military Innovation Technopolis "ERA"
Email: derev.dima1@yandex.ru
ORCID iD: 0000-0003-0370-0347
Master
Russian Federation, AnapaEvgeny A. Zhurbin
Military Innovation Technopolis "ERA"
Email: zhurbin-90@mail.ru
ORCID iD: 0000-0002-0867-3838
SPIN-code: 8426-1354
Scopus Author ID: 57198886746
Candidate of Medical Sciences
Russian Federation, AnapaPetr K. Potapov
Military Innovation Technopolis "ERA"
Email: forwardspb@mail.ru
SPIN-code: 5979-4490
Candidate of Medical Sciences
Russian Federation, AnapaReferences
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