Abstract. Factors of disadaptation of pilots after combat stress are analyzed as one of the main factors in the development of post-traumatic stress disorder. It was found that the effects of combat stress have a great impact on young, thin pilots, with a predominance of the parasympathetic division of the autonomic nervous system and a reduced basic metabolism of the body. The data obtained allow for early diagnosis and identification of functional disorders in pilots for their medical and psychological rehabilitation. The use of the proposed discriminant function can be divided into adapted and unadapted (differently processing traumatic experience), for the development of appropriate rehabilitation programs within their medical and psychological rehabilitation. The revealed decrease in the reserve capabilities of the Central nervous system and the adaptive capabilities of the body of pilots subsequently leads to a decrease in the reliability of the professional activity of the pilot with an increase in its physiological price. In terms of methodology, understanding the postponement of the negative impact of combat stress factors on the pilot’s body requires constant measures for early detection and correction of emerging functional disorders. The consequences of combat stress are considered as an integral reaction of the body to the complex impact of various factors of combat stress, which is manifested at the psychophysiological and somatic levels and leads to early disqualification of pilots for medical reasons.