Сlinical use of immune plasma in septic conditions

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Abstract


Abstract. The effectiveness of clinical use of immune plasma in comparison with conventional fresh-frozen plasma in septic conditions is considered. It was found that the use of immune plasma in the treatment of patients suffering from septic complications, against the background of antibiotic therapy, is more effective than the use of conventional freshly frozen plasma. In patients who received immune plasma transfusions, there was a significant decrease in the inflammatory response of the blood (decrease in leukocytosis, erythrocyte sedimentation rate, C-reactive protein), and the level of procalcitonin also decreased. The level of total protein, on the contrary, increased after each transfusion of this component. In patients who received fresh frozen plasma transfusion, there were no positive changes in the indicators of inflammatory blood reaction (the number of white blood cells and the rate of erythrocyte sedimentation after each transfusion increased, changes in C-reactive protein were insignificant). The level of procalcitonin and total protein increased after each infusion. In all patients who were transfused blood components, against the background of antibiotic therapy, the result of treatment was also influenced by the number of microorganisms seeded from the wound surface during primary bacteriological seeding. In General, in septic conditions, transfusion of immune plasma was more effective than transfusion of freshly frozen plasma. This effect on normalization of laboratory blood parameters was observed with a smaller average volume of transfused immune plasma (0,58 l) compared to a larger average volume (0,83 l) of transfused freshly frozen plasma.


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About the authors

L. A. Skripay

Military medical academy of S.M. Kirov

Author for correspondence.
Email: vmeda-nio@mil.ru

Russian Federation, Saint Petersburg

V. N. Vilyaninov

Military medical academy of S.M. Kirov

Email: vmeda-nio@mil.ru

Russian Federation, Saint Petersburg

N. V. Belgesov

Military medical academy of S.M. Kirov

Email: vmeda-nio@mil.ru

Russian Federation, Saint Petersburg

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Supplementary files

Supplementary Files Action
1.
Fig. 1. Average volumes of transfused blood components

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Fig. 2. The total volume of transfused blood components

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3.
Fig. 3. Dynamics of the number of leukocytes after transfusion of blood components

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4.
Fig. 4. Dynamics of ESR after transfusion of blood components

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Fig. 5. Dynamics of CRP level after transfusion of blood components

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Copyright (c) 2020 Skripay L.A., Vilyaninov V.N., Belgesov N.V.

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