Comparative value of purine metabolites in preeclampsia and acute cerebral stroke
- 作者: Oreshnikov E.V.1, Oreshnikova S.F.2, Vasilyeva E.N.3, Karpova T.V.1, Khabarova O.Y.4, Denisova T.G.5,6,7
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隶属关系:
- Emergency Hospital
- 2 City Clinical Hospital No. 1
- City Clinical Hospital No. 1
- Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
- Postgraduate Doctors’ Training Institute
- Chuvash State University named after I.N. Ulyanov
- Mari State University
- 期: 卷 23, 编号 4 (2021)
- 页面: 129-138
- 栏目: Clinical Trials
- ##submission.dateSubmitted##: 19.03.2021
- ##submission.dateAccepted##: 31.10.2021
- ##submission.datePublished##: 15.12.2021
- URL: https://journals.eco-vector.com/1682-7392/article/view/63709
- DOI: https://doi.org/10.17816/brmma63709
- ID: 63709
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详细
The values of the purine metabolites in preeclampsia and acute cerebral stroke were compared. A total of 33 patients with preeclampsia and 350 patients with an acute cerebral stroke were examined. The blood and liquor guanine, hypoxanthine, adenine, xanthine, and uric acid were determined by a direct spectrophotometry, in addition to conventional laboratory parameters. It has been established that there are clinical–pathobiochemical parallels between preeclampsia and the cerebral stroke, including by the features of purine metabolism. It is known that the most pronounced adverse metabolic indicator (marker, predictor) for both preeclampsia and the cerebral stroke is hyperuricemia. It was revealed that the favorable sign for stroke is the high values of oxypurines (hypoxanthine, xanthin, and uric acid) in the cerebrospinal fluid, and for preeclampsia their low levels. It has been shown that cerebrospinal fluid is not only the medium of administration of the drugs for spinal anesthesia, but also a source of valuable diagnostic and prognostic information, including in preeclampsia. Preeclampsia is metabolically like stroke with an unfavorable significance of hyperuricemia and diametrically antagonistic to stroke with a favorable value not increased, but a reduced concentration of hypoxanthine, xanthin, and uric acid in cerebrospinal fluid. The level of uric acid and other purines in patients suffering from a preeclampsia and in patients suffering from a cerebral stroke should be determined not only in the blood serum, but also, as far as possible, in cerebrospinal fluid.
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作者简介
Evgeny Oreshnikov
Emergency Hospital
编辑信件的主要联系方式.
Email: ev_oreshnikov@mail.ru
ORCID iD: 0000-0001-8503-0783
SPIN 代码: 9204-3618
Scopus 作者 ID: 57208311867
candidate of medical sciences, associate professor
俄罗斯联邦, CheboksarySvetlana Oreshnikova
2 City Clinical Hospital No. 1
Email: ev_oreshnikov@mail.ru
ORCID iD: 0000-0003-1056-0725
SPIN 代码: 8210-1222
candidate of medical sciences
俄罗斯联邦, CheboksaryElvira Vasilyeva
City Clinical Hospital No. 1
Email: elnikvas@mail.ru
ORCID iD: 0000-0002-7677-7735
SPIN 代码: 4988-6327
candidate of medical sciences
俄罗斯联邦, CheboksaryTatiana Karpova
Emergency Hospital
Email: ev_oreshnikov@mail.ru
candidate of medical sciences
俄罗斯联邦, CheboksaryOlga Khabarova
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation
Email: habolga@yandex.ru
ORCID iD: 0000-0003-2069-3812
SPIN 代码: 4376-8181
candidate of medical sciences
俄罗斯联邦, Sаint PetersburgTamara Denisova
Postgraduate Doctors’ Training Institute; Chuvash State University named after I.N. Ulyanov; Mari State University
Email: tomadenisova@rambler.ru
ORCID iD: 0000-0002-0517-2632
SPIN 代码: 9568-7543
Scopus 作者 ID: 57192696934
doctor of medical sciences, professor
俄罗斯联邦, Cheboksary; Cheboksary; Yoshkar-Ola参考
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