Vol 3, No 3 (2015)

At the current development stage of Russian healthcare rational use of limited financial resources for the fullest satisfaction of population's need in medicinal drugs acquires a special importance. Therefore, the issue about knowledge of experts in determination of need in drugs and evaluation of the consumption, as well as methods applied for these scientific and practical tasks resolution has a critical character. The purpose of our work is to characterize the development of research methodology of medicinal drugs need and their consumption in Russia. We have revealed the dynamics and tendencies of analyzed scientific direction development, leading scientists, principal methods, and study objects using scientometric methods of content-analysis and scientific works calculation (dissertations autoabstracts). We have established the fact of significant change of methodology beginning with 2000 comparing with a period 1970-1980s. According to authors' opinion this was conditioned by objective need in problem solving connected with pharmaceutical support in the frameworks of state guarantees.

The article reflects the features of pharmacological support of tuberculosis patients in Smolensk oblast. The participants of the process are described: the subjects of management, funding, pharmacological support. The differences between funding systems of 2008 and 2012 were characterized.

The article is devoted to the introduction of management accounting in the work of organizations (enterprises) that will improve the efficiency of administrative decisions will contribute to the flexibility and adaptability of the organization to changes in the external environment, increased productivity and efficient use of all resources of the organization.

The article shows the results of an atomic structure of a herb of Thymus dimorphus. Microdiagnostic signs were explored and determined during the study. Stem has a roundish-tetrahedral shape and a non-fascicular formation. Stomata are of the diacytic type. An availability and texture of the simple and glandular hairs are determined. So all along the Thymus dimorphus stem we have found bi- or threecellular thick-walled hairs with warty cuticle, more often they are cranked, the hairs of 5-9 cells with slightly warty surface, with grand content and glandular hairs on the bi- or threecellular stem with an elongated head and widened basal cell. There are simple unicellular hairs with slightly pointed apex and warty cuticle along the epidermis of a leaf, as well as bi- or threecellular cranked thick-walled hairs with fine-pointed apex with warty surface, the simple hairs of 4-8 cells with slightly widened cell walls and slightly warty cuticle. During the research of the flower`s parts (calyx and corolla) a kind of pubescence by the different types of hairs and a shape of epidermal cells were determined. There are essential oil glands in the epidermis of the stem, leaf, calyx and corolla. The derived research results will allow identification of a specific belonging of thymes basing on diagnostic sings.

During this study we have determined some physical and chemical characteristics of polysaccharides which are: molecular weight, Huggins constant, swelling index. The results showed that the average molecular weight of the objects under study lies from 5246 to 10071. All WSPS had swelling degree raised with the increase of molar mass while the Huggins constant decreased. The minimum value of Huggins constant were noted in berries of Grossularia reclinata which gives evidence of a good interaction of object with water which is coincide with swelling degree.

The prospects of topical formulation development with fexofenadine are conditioned by the possibility of its use in symptomatic, as well as in the combined therapy of allergic reactions on a skin, and the expansion of the pharmaceutical market of antihistamine drugs for external application. The article presents a study of a choice of optimal gel composition with fexofenadine with antiallergic action, we have also substantiated the choice of necessary auxiliary substances.

We have studied antiplatelet activity of new indole derivants on the experimental model of ADP induced aggregation of platelets in rabbit’s plasma in vitro. Seven of the studied substances exceeded comparing drug of acetylsalicylic acid on EK 50.

A number of clinical studies results of cellular therapy efficiency in different medicine fields have been collected by now. Literature data about the efficiency and safety of innovative cellular technologies were analyzed in the article. We have proved the efficiency and safety of cellular therapy although there are no approved treatment algorithms so far.

Cholagogic mixtures are effectively used for the treatment of liver diseases. We conducted a study of the mixture of the following composition: flores Helichrysi arenarii 1, herba Hyperici perforate 1, folia Urticae dioicae 1. The aim of this study is quantitative definition of rutin in cholagogic mixture by capillary electrophoresis. As a result, we have found that the cholagogic mixture contains 0,61 ± 0,02% rutin.