Том 2, № 3 (2022)

A new coronavirus infection (COVID-19) caused by SARS-Cov-2 is characterized by a variety of clinical forms and unpredictable course. To date, the virus has been found to affect not only the respiratory organs but also other systems, including the digestive tract. Typical gastrointestinal symptoms of COVID-19 include nausea, vomiting, loss of appetite to the point of anorexia, abdominal pain and diarrhea. Along with this, the examination of patients often reveals changes in biochemical parameters reflecting the functional state of the liver. Among the causes that can lead to damage to the hepatobiliary system, there are direct cytopathic or immune-mediated action of the virus on the liver, ischemia of the organ, drug-induced damage, exacerbation of existing chronic, as well as the debut of previously undiagnosed liver disease. As a rule, liver function impairment is characteristic of the stage of the developed clinical picture of COVID-19, but in some patients it can be detected during the rehabilitation period, which requires dynamic monitoring even after recovery and complete elimination of the virus. At the same time, clarification of the mechanisms of SARS-Cov-2 influence on the organism will allow to single out among the whole cohort of patients the high-risk groups for the development of certain complications of infection, and will also contribute to the development of individualized approaches to curative treatment.  This article systematizes the available data on possible etiological factors of liver damage in COVID-19 and presents our own clinical observation.

Scientific publications discuss the issues of the relationship between the results of the USE and students' academic performance, while mainly analyzing the interdependence of the exam in school and academic performance in junior courses of study. If we extrapolate these data to the period of higher medical education, we can find interesting correlations. This problem is relevant because there is a hypothesis that students studying on a contract basis are less serious about the educational process, hence, their GIA results are lower than those of budget students. The aim of the work is to evaluate the results of the state final attestation of graduates of contract and budgetary basis of education. Materials and methods. A retrospective comparative study and analysis of the results of GIA in students of medical and preventive faculty of 2022 was carried out. Statistical analysis was carried out using the methods of descriptive statistics. Results and Discussion. 382 students - graduates of USMU, among whom there were representatives of contract and budgetary forms of education, participated in all three stages of the GIA. The obtained data confirm the hypothesis about higher rates of testing and interview on the results of GIA in students of budgetary form of education in comparison with the contract form. In addition, the absence of a contract on targeted training in 6th year graduates also contributes to higher GIA results. Traditionally, a significant part of students in USMU are students of budgetary form of education (69.9 %), of which more than 50 % are on target training. The best indicators of test and interview results were in the group of students of budgetary form of education, who are not fixed by the contract on target training. Conclusion. The absence of the contract on target training, apparently, stimulates students to get higher grades in order to be competitive in the market of graduates of medical university, and to have advantages when entering clinical residency.

This work is devoted to the problem of clarifying the concept of quality of life and its manifestation at different levels of human existence. Special attention is paid to the issue of "quality of life" in medicine. The normative understanding of the quality of life is considered and it is concluded that in medical practice in determining the quality of life the existential level is the main one.

Hedonism or hedonism (from Greek "hendone" - enjoyment, pleasure) is a philosophical doctrine in which obtaining pleasure is the highest good for man, the main need, life goal and aspiration. In simple words, hedonism is a way of living in such a way as to get maximum pleasure, warding off all sorts of problems. Throughout the history of this trend hedonism has acquired different colors and at the moment it acquires a special meaning in connection with the formation of consumer society.

This article considers the problem of how instability and uncertainty affect human existence. The man is oriented on stability and predictability of the world, however, with the development of science he finds himself more and more in the world of uncertainty, plurality, instability. This circumstance forces people to change their attitude to the usual rules and values, which entails a change in thinking. Creativity of thinking, the ability to make paradoxical decisions in the moments of unpredictable turns of modern reality are brought to the forefront.