Vol 5, No 3 (2023)

The study was conducted on 38,000 36-week-old chickens of the “ROSS-308” breed. The results of a clinical study of the drug “Amoxyantare” in cases of bacterial etiology diseases in poultry are presented. Bacteriological examinations of pathological material from deceased chickens revealed the following pathogens: Staphylococcus aureus, Enterobacter agglomerans, Proteus mirabilis, and Escherichia coli. To evaluate the efficacy of the drug, four experimental groups were simultaneously formed, consisting of 4000, 13,000, 15,000, and 6000 birds, respectively. The chickens were administered Amoxyantare at a daily dose of 17.5–35 mg per 1 kg of body weight for 3–5 days. The effectiveness of the drug was assessed based on the disappearance of clinical signs of the disease and the absence of disease agents in the biomaterial after the last administration of the drug. The obtained results indicate the high efficacy of the Amoxyantare drug against Staphylococcus aureus, Enterobacter agglomerans, Proteus mirabilis, and Escherichia coli, with no observed side effects on the birds at the specified dosage.

In the previous series of articles, we examined in detail the features of the prevalence, the quality of primary registration, the localization structure and survival of patients with malignant neoplasms in various age categories of the Russian population from children and adolescents to middle age (45–59 years). In this study, we will consider all these aspects for the following age category of elderly people. In accordance with the distribution of the age structure recommended by the World Health Organization, the elderly population includes people from 60 to 79 years old. The WHO age classification is not an absolute criterion for classifying a person to a certain age structure, especially for residents of different countries, taking into account their socio-economic characteristics. The elderly age according to the university characteristic is determined by the fact that there is a decrease in vital activity. The specific features of morbidity, mortality and survival of the elderly population of Russia will be considered in detail for each five-year age group of the elderly – 60–64 years, 65–69 years, 70–74 years.

An overview of Archaea, the most ancient domain of life, was carried out. The phylogenetic relationship of Archaea with bacteria and eukaryotes are considered, and the morpho-physiological characteristics of their main groups are given. The biotechnological potential of Archaea is discussed. Cost-effective products of Archaeal biosynthesis are bacterioruberin, squalene, bacteriorhodopsin and diester/tetraether lipids. The production of other metabolic products of Archaea, such as carotenoids, hydrogen, polyhydroxyalkanoates and methane, are in advanced stages of development. While the biological production of methane and hydrogen currently lags behind the profitability of petrochemical plants, research aimed at enhancing the efficiency of this process with the involvement of Archaea holds strategic significance. Archaea also represent a promising target for application in nanotechnology and bioengineering. The aim of the present review is to unveil the biotechnological potential of Archaea, provide an overview of the main groups within this domain, their morphophysiological characteristics, present a generalized metabolite profile of these groups, and outline the spectrum of productions involving these intriguing microorganisms.

The essay is dedicated to Alexander Alekseevich Lin, Professor, Doctor of Pharmaceutical Sciences, the first head of the Department of Economics and Management of the St. Petersburg State Chemical and Pharmaceutical Academy. This essay presents his biography, contribution to pharmaceutical science and education, the results of his work, the most important scientific achievements, as well as information about the scientific, educational, methodological and organizational work of the department, which he headed. Alexander Alekseevich was awarded the prize of the Government of St. Petersburg and the certificate of honor of the Ministry of Health of the Russian Federation for outstanding achievements in the field of higher education and healthcare, as well as awarded the medal “100 years of Russian trade unions”. His vivid and significant contribution to educational activities and the sphere of public life will remain for a long time in the memory of colleagues, students and everyone who knew him. In our short essay, we used the materials of the department, archival data, bibliographic and abstract databases.