Vol 5, No 3 (2023)
- Year: 2023
- Articles: 6
- URL: https://journals.eco-vector.com/PharmForm/issue/view/8042
- DOI: https://doi.org/10.17816/phf_53
Full Issue
Pharmaceutical Sciences
Studying the therapeutic effectiveness of a new complex drug in poultry farming
Abstract
The study was conducted on 38,000 36-week-old chickens of the “ROSS-308” breed. The results of a clinical study of the drug “Amoxyantare” in cases of bacterial etiology diseases in poultry are presented. Bacteriological examinations of pathological material from deceased chickens revealed the following pathogens: Staphylococcus aureus, Enterobacter agglomerans, Proteus mirabilis, and Escherichia coli. To evaluate the efficacy of the drug, four experimental groups were simultaneously formed, consisting of 4000, 13,000, 15,000, and 6000 birds, respectively. The chickens were administered Amoxyantare at a daily dose of 17.5–35 mg per 1 kg of body weight for 3–5 days. The effectiveness of the drug was assessed based on the disappearance of clinical signs of the disease and the absence of disease agents in the biomaterial after the last administration of the drug. The obtained results indicate the high efficacy of the Amoxyantare drug against Staphylococcus aureus, Enterobacter agglomerans, Proteus mirabilis, and Escherichia coli, with no observed side effects on the birds at the specified dosage.
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Biomedical Sciences
The state of cancer care in Russia: age and cancer. Features of localization structure, quality of accounting and survival of elderly patients with ZNO (population study). Part 4
Abstract
In the previous series of articles, we examined in detail the features of the prevalence, the quality of primary registration, the localization structure and survival of patients with malignant neoplasms in various age categories of the Russian population from children and adolescents to middle age (45–59 years). In this study, we will consider all these aspects for the following age category of elderly people. In accordance with the distribution of the age structure recommended by the World Health Organization, the elderly population includes people from 60 to 79 years old. The WHO age classification is not an absolute criterion for classifying a person to a certain age structure, especially for residents of different countries, taking into account their socio-economic characteristics. The elderly age according to the university characteristic is determined by the fact that there is a decrease in vital activity. The specific features of morbidity, mortality and survival of the elderly population of Russia will be considered in detail for each five-year age group of the elderly – 60–64 years, 65–69 years, 70–74 years.
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Standard sample as an obligatory element in the diagnosis of poisoning by toxic substances
Abstract
One of the actual problems of poisoning diagnosing remains a wide variety of toxic substances and the constant emergence of new natural and synthetic compounds. Classes of compounds to which toxic substances may belong are extremely diverse. Plant, animal, bacterial and biotechnological toxins can cause acute poisoning. The difference in their physicochemical properties and chemical structure complicates the reliable and timely detection of the toxin in the human body. In the review, the authors describe the main modern diagnostic methods that allow for a qualitative and quantitative assessment of the content of the toxin. Methods of analytical control, the result of which is a quantitative characteristic of the analyzed component, in turn provide for the use of a standard sample, since this allows not only to identify the toxicant, but also to evaluate its content in the human body. The review considers the role of a standard sample in the diagnosis of poisoning by toxic substances, including in accordance with the requirements of the legislative framework of the Russian Federation in the field of ensuring the uniformity of measurements. This requirement includes ensuring the metrological traceability of measurement results, monitoring the accuracy of measurement results, conducting validation and verification procedures for analytical methods that require the use of a certified standard sample. The main problems specialists face in the process of diagnosing and determining the direction of activity for their solution are indicated. Today, the need to develop domestic analytical standards is becoming important, which is associated with the difficulties of acquiring them in other countries and restricting the access of the Russian Federation to world biobanks, storages of reference samples.
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Biological sciences
Domain Archaea – system overview, metabolism, biotechnological potential
Abstract
An overview of Archaea, the most ancient domain of life, was carried out. The phylogenetic relationship of Archaea with bacteria and eukaryotes are considered, and the morpho-physiological characteristics of their main groups are given. The biotechnological potential of Archaea is discussed. Cost-effective products of Archaeal biosynthesis are bacterioruberin, squalene, bacteriorhodopsin and diester/tetraether lipids. The production of other metabolic products of Archaea, such as carotenoids, hydrogen, polyhydroxyalkanoates and methane, are in advanced stages of development. While the biological production of methane and hydrogen currently lags behind the profitability of petrochemical plants, research aimed at enhancing the efficiency of this process with the involvement of Archaea holds strategic significance. Archaea also represent a promising target for application in nanotechnology and bioengineering. The aim of the present review is to unveil the biotechnological potential of Archaea, provide an overview of the main groups within this domain, their morphophysiological characteristics, present a generalized metabolite profile of these groups, and outline the spectrum of productions involving these intriguing microorganisms.
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Correction of piglets’ immune status during critical growing periods
Abstract
The research was conducted under industrial conditions at the breeding enterprise “Verdazernoprodukt” in the Saraevsky district of the Ryazan region on 1380 piglets. All experimental piglets were divided into 2 test groups of 690 individuals each. The piglets in the first experimental group, from the age of 16 days, were orally provided with a feed mixture “Energy” at a dosage of 250 mg/kg of body weight for one month. The piglets in the second experimental group served as the control and received a standard diet typically used at the farm. Positive effects of the adaptogen on the immune system parameters of the piglets during the weaning period were identified. The experiment revealed that administering the tested feed mixture to the weaned piglets during the growing period contributed to the activation of metabolic processes in the body, enhanced natural resistance, improved nutrient absorption, and resulted in higher average daily weight gains.
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Heritage
About the first head of the Department of Economics and Management, Professor Lin Alexander Alekseevich
Abstract
The essay is dedicated to Alexander Alekseevich Lin, Professor, Doctor of Pharmaceutical Sciences, the first head of the Department of Economics and Management of the St. Petersburg State Chemical and Pharmaceutical Academy. This essay presents his biography, contribution to pharmaceutical science and education, the results of his work, the most important scientific achievements, as well as information about the scientific, educational, methodological and organizational work of the department, which he headed. Alexander Alekseevich was awarded the prize of the Government of St. Petersburg and the certificate of honor of the Ministry of Health of the Russian Federation for outstanding achievements in the field of higher education and healthcare, as well as awarded the medal “100 years of Russian trade unions”. His vivid and significant contribution to educational activities and the sphere of public life will remain for a long time in the memory of colleagues, students and everyone who knew him. In our short essay, we used the materials of the department, archival data, bibliographic and abstract databases.
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